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1. (WO2005014524) AMINO THIOL COMPOUNDS AND COMPOSITIONS FOR USE IN CONJUNCTION WITH CANCER THERAPY
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2005/014524 International Application No.: PCT/US2004/026535
Publication Date: 17.02.2005 International Filing Date: 09.08.2004
IPC:
C07C 211/14 (2006.01) ,C07C 211/22 (2006.01) ,C07C 215/18 (2006.01) ,C07C 215/24 (2006.01) ,C07C 323/25 (2006.01) ,C07C 323/27 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
211
Compounds containing amino groups bound to a carbon skeleton
01
having amino groups bound to acyclic carbon atoms
02
of an acyclic saturated carbon skeleton
14
Amines containing amino groups bound to at least two aminoalkyl groups, e.g. diethylenetriamines
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
211
Compounds containing amino groups bound to a carbon skeleton
01
having amino groups bound to acyclic carbon atoms
20
of an acyclic unsaturated carbon skeleton
22
containing at least two amino groups bound to the carbon skeleton
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
215
Compounds containing amino and hydroxy groups bound to the same carbon skeleton
02
having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
04
the carbon skeleton being saturated
06
and acyclic
18
with hydroxy groups and at least two amino groups bound to the carbon skeleton
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
215
Compounds containing amino and hydroxy groups bound to the same carbon skeleton
02
having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
22
the carbon skeleton being unsaturated
24
and acyclic
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
323
Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
23
containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
24
having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
25
the carbon skeleton being acyclic and saturated
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
323
Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
23
containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
24
having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
27
the carbon skeleton being acyclic and unsaturated
Applicants: FAHL, William, E.[US/US]; US (UsOnly)
PEEBLES, Daniel, D.[US/US]; US (UsOnly)
COPP, Richard, R.[US/US]; US (UsOnly)
WISCONSIN ALUMNI RESEARCH FOUNDATION[US/US]; 614 Walnut Street Madison, WI 53705, US (AllExceptUS)
Inventors: FAHL, William, E.; US
PEEBLES, Daniel, D.; US
COPP, Richard, R.; US
Agent: REED, Janet, E. ; Woodcock Washburn LLP One Liberty Place - 46th Floor Philadelphia, PA 19103, US
Priority Data:
60/493,21807.08.2003US
Title (EN) AMINO THIOL COMPOUNDS AND COMPOSITIONS FOR USE IN CONJUNCTION WITH CANCER THERAPY
(FR) COMPOSES D'AMINO THIOL ET COMPOSITIONS DESTINES A ETRE UTILISES CONJOINTEMENT AVEC UN TRAITEMENT DU CANCER
Abstract:
(EN) The invention provides novel polyamine and amino thiol compounds and pharmaceutical compositions for administration in conjunction with cancer chemotherapy or radiation therapy. The compounds are administered locally to provide protection against the adverse side-effects of chemotherapy or radiation therapy, such as alopecia, mucositis and dermatitis. Pharmaceutical preparations comprising one or more chernoprotective polyamines or amino thiols formulated for topical or local delivery to epithelial or mucosal cells are disclosed. Methods of administering the pharmaceutical preparations are also disclosed.
(FR) L'invention concerne de nouveaux composés d'amino thiol et de polyamine et des compositions pharmaceutiques, destinés à être administrés conjointement à une chimiothérapie ou à une radiothérapie anticancéreuse. Lesdits composés sont administrés localement pour assurer une protection contre les effets indésirables de la chimiothérapie ou de la radiothérapie, de type alopécie, mucosite et dermatite. L'invention concerne également des préparations pharmaceutiques comprenant une ou plusieurs polyamines chimioprotectrices ou un ou plusieurs amino thiols chimioprotecteurs formulés à des fins d'administration topique ou locale sur des cellules épithéliales ou sur des cellules de muqueuses. L'invention concerne en outre des méthodes d'administration desdites préparations pharmaceutiques.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)