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1. (WO2005014110) CPG-PACKAGED LIPOSOMES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2005/014110 International Application No.: PCT/EP2004/008190
Publication Date: 17.02.2005 International Filing Date: 22.07.2004
IPC:
A61K 39/39 (2006.01)
Applicants: BACHMANN, Martin, F.[CH/CH]; CH (UsOnly)
MANOLOVA, Vania[BG/CH]; CH (UsOnly)
STORNI, Tazio[CH/CH]; CH (UsOnly)
CYTOS BIOTECHNOLOGY AG[CH/CH]; Wagistrasse 25 CH-8952 Schlieren, CH (AllExceptUS)
Inventors: BACHMANN, Martin, F.; CH
MANOLOVA, Vania; CH
STORNI, Tazio; CH
Agent: WICHMANN, Hendrik; Isenbruck Bösl Hörschler Wichmann Huhn Prinzregentenstrasse 68 81675 München, DE
Priority Data:
60/488,79922.07.2003US
Title (EN) CPG-PACKAGED LIPOSOMES
(FR) LIPOSOMES A CPG EMBALLEES
Abstract:
(EN) Liposomes are known to enhance the activity of K- (B-) type CpGs which trigger the production of IL-12. In the present invention, the surprising finding was made that liposomes also enhance the activity of D- (A-) type CpGs, leading to the production of IFN&agr; in vivo. These findings are relevant for the humans situation, since IFN&agr; rather than IL-12 is the key cytokine for the induction of Th I responses and anti-viral protection in humans.
(FR) Les liposomes sont connus pour accroître l'activité des CpG de type K- (B-) déclenchant la production de IL-12. Les liposomes selon l'invention augmentent également l'activité des CpG de type D- (A-), entraînant la production de IFNa in vivo. Ces liposomes présentent un intérêt particulier pour l'être humain, du fait que IFNa, plutôt que IL-12, est la cytokine clé pour l'induction des réponses de Th1 et la protection antivirale chez l'être humain.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)