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1. (WO2005013975) INDOLAMIDE DERIVATIVES WHICH POSSESS GLYCOGEN PHOSPHORYLASE INHIBITORY ACTIVITY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/013975    International Application No.:    PCT/GB2004/003364
Publication Date: 17.02.2005 International Filing Date: 04.08.2004
IPC:
C07D 209/42 (2006.01)
Applicants: ASTRAZENECA AB [SE/SE]; Sodertalje, S-151 85 (SE) (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MC, MD, MK, ML, MN, MR, MW, MX, MZ, NA, NE, NI, NL, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SI, SK, SL, SN, SY, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, YU, ZA, ZM, ZW only).
ASTRAZENECA UK LIMITED [GB/GB]; 15 Stanhope Gate, London, Greater London W1K 1LN (GB) (MG only).
BIRCH, Alan, Martin [GB/GB]; (GB) (For US Only).
BENNETT, Stuart, Norman, Lile [GB/GB]; (GB) (For US Only).
GODFREY, Linda [GB/GB]; (GB) (For US Only).
SIMPSON, Iain [GB/GB]; (GB) (For US Only).
WHITTAMORE, Paul, Robert, Owen [GB/GB]; (GB) (For US Only)
Inventors: BIRCH, Alan, Martin; (GB).
BENNETT, Stuart, Norman, Lile; (GB).
GODFREY, Linda; (GB).
SIMPSON, Iain; (GB).
WHITTAMORE, Paul, Robert, Owen; (GB)
Agent: ASTRAZENECA; Global Intellectual Property, S-151 85 Sodertalje (SE)
Priority Data:
0318464.5 07.08.2003 GB
Title (EN) INDOLAMIDE DERIVATIVES WHICH POSSESS GLYCOGEN PHOSPHORYLASE INHIBITORY ACTIVITY
(FR) DERIVES D'INDOLAMIDE POSSEDANT UNE ACTIVITE INHIBITRICE DE LA GLYCOGENE PHOSPHORYLASE
Abstract: front page image
(EN)A compound of the formula (1) or a pharmaceutically-acceptable salt wherein, for example, A is phenylene or heteroarylene; Y is selected from -C(O)R2 , -C(O)OR2, -C(O)NR2R3, -(1-4C)alkyl [optionally substituted] -(2-4C)alkenyl, -SO2NR2R3, and -S(O)CR2 (wherein c is 0, 1 or 2); compounds which possess glycogen phosphorylase inhibitory activity and accordingly have value in the treatment of disease states associated with increased glycogen phosphorylase activity. Processes for the manufacture of compounds and pharmaceutical compositions containing them are described.
(FR)L'invention concerne un composé représenté par la formule (1) ou un sel pharmaceutiquement acceptable, (1) dans lequel, par exemple, A représente par phenylène or hétéroarylène; Y est choisi parmi -C(O)R2, -C(O)OR2, -C(O)NR2R3, - alkyl(C1-4) [éventuellement substitué] alcényle-(C2-4), -SO2NR2R3, et -S(O)CR2 (où c représente 0, 1 ou 2). Ces composés possèdent une activité inhibitrice de la glycogènes phosphorylase, et sont par conséquent intéressants pour le traitement d'états pathologiques associés à une activité accrue de la glycogène phorphorylase. L'invention concerne en outre des procédés permettant de produire ces composés et des compositions pharmaceutiques les contenant.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)