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1. (WO2005013900) METHOD AND COMPOSITION FOR TREATING PERIDONTAL DISEASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/013900    International Application No.:    PCT/US2004/025205
Publication Date: 17.02.2005 International Filing Date: 04.08.2004
IPC:
A61K 31/4709 (2006.01), A61K 31/557 (2006.01), A61K 31/65 (2006.01), A61K 31/704 (2006.01), A61K 45/06 (2006.01)
Applicants: REGENA THERAPEUTICS LC [US/US]; 2501 North Loop Drive, Suite 1618, Ames, Iowa 50010 (US)
Inventors: MCKEE, Rex; (US).
WINGROVE, Frank; (US)
Agent: POCHOPIEN, Donald, J.; McAndrews, Held & Malloy, Ltd., 500 W. Madison Street, Suite 3400, Chicago, Illinois 60661 (US)
Priority Data:
10/635,144 06.08.2003 US
Title (EN) METHOD AND COMPOSITION FOR TREATING PERIDONTAL DISEASE
(FR) PROCEDE ET COMPOSITION SERVANT A TRAITER UNE MALADIE PERIODONTIQUE
Abstract: front page image
(EN)The present invention is directed to a pharmaceutical composition comprising a therapeutically effective amount of misoprostol and an effective amount of an antibiotic. A suitable antibiotic is selected from the group consisting of doxycycline, gentamicin, tobramicin, ciprofloxacin, clindamycin, clarithromycin, azithromycin and metronidazole. Preferred antibiotics are doxycycline and ciprofloxacin. More preferably, the antibiotic is doxycycline. In its second aspect, the present invention is directed to a method for treating periodontal disease in a mammalian patient comprising administering to a mammalian patient in need of such treatment a therapeutically effective amount of misoprostol and an effective amount of an antibiotic. Typically, the mammalian patient is a human.
(FR)L'invention concerne une composition pharmaceutique contenant une quantité efficace sur le plan thérapeutique de misoprostol et une quantité efficace d'antibiotique. Un antibiotique approprié sélectionné dans le groupe constitué par doxycycline, gentamicine, tobramicine, ciprofloxacine, clindamycine, clarithromycine, azithromycine et metronidazole. Les antibiotiques préférés sont doxycycline et ciprofloxacine. Dans un mode de réalisation préféré, cet antibiotique sera doxycycline. Dans son deuxième aspect, l'invention concerne un procédé servant à traiter une maladie périodontique chez un mammifère et consistant à administrer à ce dernier une quantité efficace sur le plan thérapeutique de misoprostol et une quantité efficace d'antibiotique. Ce patient mammifère consiste généralement en un humain.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)