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1. (WO2005012568) IN VITRO GENE EXPRESSION ASSAY FOR DETERMINING FLUOROPYRIMIDINE SENSITIVITY IN CHEMOTHERAPY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/012568    International Application No.:    PCT/GB2004/003342
Publication Date: 10.02.2005 International Filing Date: 30.07.2004
IPC:
C12Q 1/68 (2006.01)
Applicants: THE QUEEN'S UNIVERSITY OF BELFAST [GB/GB]; University Road, Belfast BT7 1NN (GB) (For All Designated States Except US).
JOHNSTON, Patrick, Gerard [GB/GB]; (GB) (For US Only).
LONGLEY, David, Broderick [GB/GB]; (GB) (For US Only).
MAXWELL, Pamela, Joan [GB/GB]; (GB) (For US Only)
Inventors: JOHNSTON, Patrick, Gerard; (GB).
LONGLEY, David, Broderick; (GB).
MAXWELL, Pamela, Joan; (GB)
Agent: MURGITROYD & COMPANY; Scotland House, 165-169 Scotland Street, Glasgow G5 8PL (GB)
Priority Data:
0317826.6 30.07.2003 GB
Title (EN) IN VITRO GENE EXPRESSION ASSAY FOR DETERMINING FLUOROPYRIMIDINE SENSITIVITY IN CHEMOTHERAPY
(FR) PROCEDE D'ESSAI
Abstract: front page image
(EN)Methods of determining susceptibility to resistance to anti-cancer drugs such as fluoropyrimidines, antimetabolites and platinum-containing compounds are described. DNA microarray technology was used to investigate changes in the transcriptional profile of the MCF-7 breast cancer cell line following treatment with fluoropyrimidines. Upregulated genes included the genes encoding Raf, K-ras, SLAP, phosphoinositide 3-kinase, COP9 homolog (HCOP9), apoptosis specific protein, APO-1 cell surface antigen, FLIP protein, cyclin G, CDC2 , cyclin­-dependent protein kinase -2, thymosin &bgr;-10, myosin light chain (MLC-2), gelsolin, thymosin &bgr;-4, SSAT, spermidine synthase, spermidine aminopropyltransferase, MAT-8 protein, annexin II, annexin IV, FGF receptor 2, transmembrane 4 superfamily protein, chaperonin 10, enoyl-CoA hydratase, nicotinamide nucleotide transhydrogenase, ribosomal protein S28, ribosomal protein L37, L23 mRNA for putative ribosomal protein, and ribosomal protein L7. Also described are assays for identifying novel chemotherapeutic agents.
(FR)L'invention concerne des procédés de détermination d'une prédisposition à résister à des médicaments anticancéreux tels que les fluoropyrimidines, les antimétabolites et les composés contenant du platine. La technologie des microréseaux à ADN a été mise en oeuvre pour la recherche de modifications du profil transcriptionnel de la lignée cellulaire du cancer du sein MCF-7 après un traitement avec les fluoropyrimidines. Les gènes régulés positivement comprennent les gènes codant Raf, K-ras, SLAP, la phosphoinositide 3-kinase, l'homologue de COP9 (HCOP9), la protéine spécifique à l'apoptose, l'antigène de surface cellulaire APO-1, la protéine FLIP, la cycline G, CDC2, la protéine kinase 2 cyclinodépendante, la thymosine $g(b)-10, la chaîne légère de myosine (MLC-2), la gelsoline, la thymosine $g(b)-4, SSAT, la spermidine synthase, la spermidine aminopropyltransférase, la protéine MAT-8, l'annexine II, l'annexine IV, le récepteur du FGF 2, la protéine de la superfamille 4 transmembranaire, la chaperonine 10, l'énoyl-CoA hydratase, la nicotinamide nucléotide transhydrogénase, la protéine ribosomique S28, la protéine ribosomique L37, l'ARNm L23 pour la protéine ribosomique présumée, et la protéine ribosomique L7. L'invention concerne également des essais permettant l'identification de nouveaux agents chimiothérapeutiques.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)