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Machine translation
1. (WO2005012238) PROCESS FOR THE PREPARATION OF CPLA2 INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/012238    International Application No.:    PCT/US2004/023247
Publication Date: 10.02.2005 International Filing Date: 19.07.2004
IPC:
C07C 303/40 (2006.01), C07C 311/13 (2006.01)
Applicants: WYETH [US/US]; Five Giralda Farms, Madison, NJ 07940 (US) (For All Designated States Except US).
WU, Yanzhong [US/US]; (US) (For US Only).
RAVEENDRANATH, Panolil [US/US]; (US) (For US Only)
Inventors: WU, Yanzhong; (US).
RAVEENDRANATH, Panolil; (US)
Agent: CALNAN, William, H.; Wyeth, Patent Law Department, Five Giralda Farms, Madison, NJ 07940 (US)
Priority Data:
60/490,005 25.07.2003 US
Title (EN) PROCESS FOR THE PREPARATION OF CPLA2 INHIBITORS
(FR) PROCEDE DE PREPARTION D'INHIBITEURS CPLA2
Abstract: front page image
(EN)A process for making a compound of formula (I) in which process the compound HC≡C-(CH2)n-NH2 is reacted with the compound R1-SO2Cl to produce an intermediate compound, which intermediate compound is then reacted with the compound of formula (II) to produce the compound of formula (I). The terms R1, R2, R3, R4 and n have the definitions set forth in the claims. The compounds of formula (I) are useful in the preparation of indole derivatives of formula (V) which are cPLA2 inhibitors.
(FR)L'invention concerne un procédé de préparation d'un composé représenté par la formule (I). Dans ce procédé le composé HC=C-(CH2)n-NH2 est mis en réaction avec le composé R1-SO2Cl afin de produire un composé intermédiaire, ce composé intermédiaire étant mis en réaction avec le composé de la formule (II) afin de produire le composé de formule (I). R1, R2, R3, R4 et n sont définis dans les revendications. Les composés représentés par la formule (I) sont utilisés dans la préparation de dérivés d'indole de formule (V), lesquels sont des inhibiteurs cPLA2.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)