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Machine translation
1. (WO2005012234) COMPOUNDS FOR MODULATING CELL PROLIFERATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/012234    International Application No.:    PCT/CA2004/001431
Publication Date: 10.02.2005 International Filing Date: 30.07.2004
Chapter 2 Demand Filed:    11.05.2005    
IPC:
A61K 31/4402 (2006.01), C07C 255/41 (2006.01), C07C 323/46 (2006.01), C07D 213/71 (2006.01)
Applicants: THE HOSPITAL FOR SICK CHILDREN [CA/CA]; 555 University Avenue, Suite 5270, Toronto, Ontario M5G 1X8 (CA) (For All Designated States Except US).
ROIFMAN, Chaim, M. [CA/CA]; (CA) (For US Only).
DEMIN, Peter [CA/CA]; (CA) (For US Only).
ROUNOVA, Olga [RU/CA]; (CA) (For US Only).
GRUNBERGER, Thomas [CA/CA]; (CA) (For US Only).
CIMPEAN, Octavian, Laurand [CA/CA]; (CA) (For US Only)
Inventors: ROIFMAN, Chaim, M.; (CA).
DEMIN, Peter; (CA).
ROUNOVA, Olga; (CA).
GRUNBERGER, Thomas; (CA).
CIMPEAN, Octavian, Laurand; (CA)
Agent: SMART & BIGGAR; Attn: KANG, Yoon (Ms.), 438 University Avenue, Suite 1500, Box 111, Toronto, Ontario M5G 2K8 (CA)
Priority Data:
60/491,109 30.07.2003 US
Title (EN) COMPOUNDS FOR MODULATING CELL PROLIFERATION
(FR) COMPOSES DESTINES A MODULER LA PROLIFERATION CELLULAIRE
Abstract: front page image
(EN)Compounds having the Formula (I) or (III) wherein R1, R2 and R3 are each independently selected from H, OH, C1-6alkyl, C1-6alkoxy, NH2, NH-(Cl-6a1kyl), N(C1-6a1kyl)(C1-6alkyl), SH, S-C1-6alkyl, NO2, CF3, OCF3, and halo; R4 is unsubstituted Ar or Ar substituted with 1-4 substituents independently selected from C1-6alkyl, C1-6alkoxy and halo; X is selected from (CH2CH2O)n and (CH)n, and n = 1-4, salts, solvates and hydrates thereof, useful for modulating or inhibiting cell proliferation, are described.
(FR)L'invention concerne des composés représentés par la formule (I) ou (III), dans laquelle R1, R2 et R3 sont chacun indépendamment choisis parmi H, OH, C1-6alkyle, C1-6alcoxy, NH2, NH-(C1-6alkyle), N(C1-6alkyle)(C1-6alkyle), SH, S-C1-6alkyle, NO2, CF3, OCF3 et halo, R4 est Ar non substitué ou Ar substitué par 1 à 4 substituants indépendamment choisis parmi C1-6alkyle, C1-6alcoxy et halo, X est choisi parmi (CH2CH2O)n et (CH)n, et n = 1 à 4. L'invention concerne également des sels, des solvates et des hydrates de ces composés, lesquels sont utiles pour moduler ou inhiber la prolifération cellulaire.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)