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Machine translation
1. (WO2005011655) PYRIDAZINE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/011655    International Application No.:    PCT/US2004/024548
Publication Date: 10.02.2005 International Filing Date: 29.07.2004
IPC:
A61K 31/00 (2006.01), A61K 31/501 (2006.01), A61K 31/551 (2006.01), C07D 237/20 (2006.01), C07D 237/24 (2006.01)
Applicants: XENON PHARMACEUTICALS INC. [CA/CA]; 3650 Gilmore Way, Burnaby, British Columbia V5G 4W8 (CA) (For All Designated States Except US).
ABREO, Melwyn [US/US]; (US) (For US Only).
CHAFEEV, Mikhail [RU/CA]; (CA) (For US Only).
CHAKKA, Nagasree [CA/CA]; (CA) (For US Only).
CHOWDHURY, Sultan [CA/CA]; (CA) (For US Only).
FU, Jian-Min [CA/CA]; (CA) (For US Only).
GSCHWEND, Heinz, W. [US/US]; (US) (For US Only).
HOLLADAY, Mark, W. [US/US]; (US) (For US Only).
HOU, Duanjie [CA/CA]; (CA) (For US Only).
KAMBOJ, Rajender [CA/CA]; (CA) (For US Only).
KODUMURU, Vishnumurthy [CA/CA]; (CA) (For US Only).
LI, Wenbao [CN/US]; (US) (For US Only).
LIU, Shifeng [CA/CA]; (CA) (For US Only).
RAINA, Vandna [IN/CA]; (CA) (For US Only).
SUN, Sengen [CA/US]; (US) (For US Only).
SUN, Shaoyi [CA/CA]; (CA) (For US Only).
SVIRIDOV, Serguei [CA/CA]; (CA) (For US Only).
TU, Chi [US/US]; (US) (For US Only).
WINTHER, Michael, D. [CA/CA]; (CA) (For US Only).
ZHANG, Zaihui [CA/CA]; (CA) (For US Only)
Inventors: ABREO, Melwyn; (US).
CHAFEEV, Mikhail; (CA).
CHAKKA, Nagasree; (CA).
CHOWDHURY, Sultan; (CA).
FU, Jian-Min; (CA).
GSCHWEND, Heinz, W.; (US).
HOLLADAY, Mark, W.; (US).
HOU, Duanjie; (CA).
KAMBOJ, Rajender; (CA).
KODUMURU, Vishnumurthy; (CA).
LI, Wenbao; (US).
LIU, Shifeng; (CA).
RAINA, Vandna; (CA).
SUN, Sengen; (US).
SUN, Shaoyi; (CA).
SVIRIDOV, Serguei; (CA).
TU, Chi; (US).
WINTHER, Michael, D.; (CA).
ZHANG, Zaihui; (CA)
Agent: OSHA LIANG L.L.P.; 1221 McKinney, Suite 2800, Houston, TX 77010 (US)
Priority Data:
60/491,095 30.07.2003 US
60/546,898 23.02.2004 US
60/546,934 23.02.2004 US
60/546,815 23.02.2004 US
60/546,820 23.02.2004 US
60/546,786 23.02.2004 US
60/553,403 16.03.2004 US
60/553,446 16.03.2004 US
60/553,491 16.03.2004 US
60/553,416 16.03.2004 US
60/553,404 16.03.2004 US
Title (EN) PYRIDAZINE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS
(FR) DERIVES DE PYRIDAZINE ET LEUR UTILISATION EN TANT QU'AGENTS THERAPEUTIQUES
Abstract: front page image
(EN)Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I), where x, y, W, V, R2, R3, R4, R5, R6, R6a, R7, R7a, R8, R8a, R9 and R9a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
(FR)L'invention concerne des procédés de traitement d'une maladie ou d'une condition induite par SCD chez un mammifère, de préférence un être humain, ce procédé consistant à administrer à un mammifère le nécessitant un composé représenté par la formule (I). Dans cette formule x, y, W, V, R2, R3, R4, R5, R6, R6a, R7, R7a, R8, R8a, R9 et R9a y sont définis. L'invention concerne également des compositions pharmaceutiques comprenant les composés représentés par la formule (I).
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)