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Machine translation
1. (WO2005011601) 6-MENBERED HETEROARYL COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/011601    International Application No.:    PCT/US2004/024821
Publication Date: 10.02.2005 International Filing Date: 30.07.2004
IPC:
C07D 211/44 (2006.01), C07D 211/54 (2006.01), C07D 211/72 (2006.01), C07D 215/10 (2006.01), C07D 413/00 (2006.01), C07D 417/00 (2006.01), C07D 417/04 (2006.01)
Applicants: PFIZER PRODUCTS, INC. [US/US]; Eastern Point Road, Groton, CT 06340 (US) (For All Designated States Except US).
CHEN, Yuhpyng, L. [US/US]; (US) (For US Only)
Inventors: CHEN, Yuhpyng, L.; (US)
Agent: GROLZ, Edward, W.; Scully, Scott, Murphy & Presser, 400 Garden City Plaza, Garden City, NY 11530 (US)
Priority Data:
60/492,088 01.08.2003 US
Title (EN) 6-MENBERED HETEROARYL COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS
(FR) COMPOSES HETEROARYLE A 6 ELEMENTS POUR TRAITER DES TROUBLES NEURODEGENERATIFS
Abstract: front page image
(EN)The present invention relates to compounds of the Formula wherein R1, R1a, R1b, R2,, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, X, Y, W, U, Z, m and n are as definited. Compounds of the Formula (I) have activity inhibiting production of A&bgr;-peptide. This invention also relates to pharmatical compositions and methods of treating diseases, for example, neurodegenerative diseases, e.g., Alzheimer’s disease, in a mammal comprising compounds of the Formula (I).
(FR)La présente invention concerne des composés de formule (I) dans laquelle R1, R1a, R1b, R2,, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, X, Y, W, U, Z, m et n sont tels que définis. Les composés de formule (I) présentent une activité d'inhibition de la production de peptide $g(b)A. La présente invention concerne également des compositions pharmaceutiques et des procédés pour traiter des maladies chez un mammifère, par exemple des maladies neurodégénératives telles que la maladie d'Alzheimer, impliquant des composés de formule (I).
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)