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Machine translation
1. (WO2005011599) ANTIBODIES SPECIFIC FOR TOXIC AMYLOID BETA PROTEIN OLIGOMERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/011599    International Application No.:    PCT/US2004/024794
Publication Date: 10.02.2005 International Filing Date: 02.08.2004
IPC:
A61K 39/395 (2006.01)
Applicants: NORTHWESTERN UNIVERSITY [US/US]; 1880 Oak Avenue, Suite 100, Evanston, IL 60201 (US) (For All Designated States Except US).
LADU, Mary, Jo [US/US]; (US) (For US Only).
BINDER, Lester [US/US]; (US) (For US Only).
STINE, Blaine, I. [US/US]; (US) (For US Only).
MANELLI, Arlene [US/US]; (US) (For US Only)
Inventors: LADU, Mary, Jo; (US).
BINDER, Lester; (US).
STINE, Blaine, I.; (US).
MANELLI, Arlene; (US)
Agent: CASIMIR, David, A.; Medlen & Carroll, LLP, 101 Howard Street, Suite 203, San Francisco, CA 94105 (US)
Priority Data:
60/491,725 01.08.2003 US
10/909,597 02.08.2004 US
Title (EN) ANTIBODIES SPECIFIC FOR TOXIC AMYLOID BETA PROTEIN OLIGOMERS
(FR) ANTICORPS SPECIFIQUES DES OLIGOMERES A PROTEINES BETA AMYLOIDES TOXIQUES
Abstract: front page image
(EN)The present invention provides compositions and methods for diagnosing Alzheimer's disease (AD). In particular, the present invention provides monoclonal antibodies that specifically bind to soluble, non-fibrillar oligomeric amyloid &bgr; protein assemblies proteolytically derived from the transmembrane amyloid precursor protein (APP) while not reacting with fibrillar amyloid &bgr; protein assemblies, monoclonal antibodies that specifically bind to fibrillar amyloid &bgr; protein assemblies that do not react with soluble, non-fibrillar oligomeric amyloid &bgr; protein assemblies, and methods of use of these compositions in the diagnosis of Alzheimer's disease, as well as methods to monitor treatment and/or disease progression of AD in patients.
(FR)La présente invention concerne des compositions et des techniques de diagnostic de la maladie d'Alzheimer (AD). Cette invention concerne en particulier des anticorps monoclonaux qui se lient spécifiquement à des ensembles de protéines bêta amyloïdes oligomères sans fibrilles dérivés de manière protéolytique de la protéine précurseur amyloïde transmembranaire (APP) sans réagir avec des ensembles de protéines bêta amyloïdes à fibrilles. Cette invention concerne aussi des anticorps monoclonaux qui se lient spécifiquement à des ensembles de protéines bêta amyloïdes à fibrilles qui ne réagissent pas avec des ensemble de protéines bêta amyloïdes oligomères sans fibrilles et des techniques d'utilisation de ces compositions dans le diagnostic de la maladie d'Alzheimer, ainsi que des techniques de surveillance de traitement et/ou de progression de la maladie d'Alzheimer chez des patients.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)