WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2005011573) NOVEL THERAPEUTIC AGENTS FOR THE TREATMENT OF CANCER, METABOLIC DISEASES AND SKIN DISORDERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/011573    International Application No.:    PCT/US2004/023562
Publication Date: 10.02.2005 International Filing Date: 21.07.2004
IPC:
C07C 49/713 (2006.01)
Applicants: AUSPEX PHARMACEUTICALS, INC. [US/US]; 1261 Liberty Way, Suite C, Vista, CA 92083 (US) (For All Designated States Except US).
TSE, Bruno [GB/US]; (US) (For US Only).
SARSHAR, Sepehr [US/US]; (US) (For US Only)
Inventors: TSE, Bruno; (US).
SARSHAR, Sepehr; (US)
Agent: HAILE, Lisa, A.; Gray Cary Ware & friedenrich LLP, 4365 Executive Drive, Suite 1100, San Diego, California 92121-2133 (US)
Priority Data:
60/492,099 01.08.2003 US
Title (EN) NOVEL THERAPEUTIC AGENTS FOR THE TREATMENT OF CANCER, METABOLIC DISEASES AND SKIN DISORDERS
(FR) NOUVEAUX AGENTS THERAPEUTIQUES POUR LE TRAITEMENT DU CANCER, DE MALADIES METABOLIQUES ET DE TROUBLES DERMIQUES
Abstract: front page image
(EN)The present invention is directed to compounds having the structure wherein R1, R2, R3, R4, R,5 and m are as defined herein. The compounds of this invention are novel therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders in mammalian subjects. These compounds are also useful modulators of gene expression. They exert their activity by interfering with certain cellular signal transduction cascades. The compounds of the invention are thus also useful for regulating cell differentiation and cell cycle processes that are controlled or regulated by various hormones or cytokines. In particular, the invention relates to compounds that induce apoptosis of cancer cells and therefore may be used for the treatment or prevention of cancer, including advanced cancers and pre-cancerous cells. The invention also discloses pharmaceutical compositions and methods of treatment of disease in mammals.
(FR)L'invention concerne des composés présentant la structure (I). Dans cette structure R1, R2, R3, R4, R5 et m sont définis dans la description. Les composés de cette invention constituent de nouveaux agents thérapeutiques pour le traitement du cancer, de maladies métaboliques et de troubles dermiques chez des mammifères. Ces composés constituent également des modulateur utiles d'expression génique. Ils exercent leur activité en interférant sur certaines cascades de transduction de signal cellulaire. Les composés de l'invention sont également utiles pour réguler les procédés de différenciation cellulaire et de cycle cellulaire contrôlés ou régulés par des hormones ou des cytokines variés. En particulier, l'invention concerne des composés induisant l'apoptose de cellules cancéreuses, et par conséquent ces composés s'avèrent utiles pour le traitement ou pour la prévention du cancer, notamment de cancers avancés et de cellules précancéreuses. L'invention concerne encore des compositions pharmaceutiques et des méthodes de traitement de maladies chez les mammifères.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)