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Machine translation
1. (WO2005010045) COMPOSITIONS AND METHODS RELATING TO MULTIMERIC AND OLIGOMERIC SOLUBLE FRAGMENTS OF THE TWEAK RECEPTOR
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2005/010045 International Application No.: PCT/US2004/023904
Publication Date: 03.02.2005 International Filing Date: 23.07.2004
IPC:
C07K 14/705 (2006.01)
Applicants: WILEY, Steven, R.[US/US]; US (UsOnly)
AMGEN INC.[US/US]; One Amgen Center Drive Thousand Oaks, CA 91320-1799, US (AllExceptUS)
Inventors: WILEY, Steven, R.; US
Agent: MACHIN, Nathan, A.; Amgen Inc. 1201 Amgen Court West Seattle, WA 98119-3105, US
Priority Data:
60/490,03624.07.2003US
Title (EN) COMPOSITIONS AND METHODS RELATING TO MULTIMERIC AND OLIGOMERIC SOLUBLE FRAGMENTS OF THE TWEAK RECEPTOR
(FR) COMPOSITIONS ET PROCEDES AYANT TRAIT FRAGMENTS SOLUBLES MULTIMERIQUES ET OLIGOMERIQUES DANS LE RECEPTEUR TWEAK
Abstract:
(EN) The present invention provides methods and compositions relating to fusion proteins comprising multimeric soluble TWEAK receptor fragments and an oligomerization domain. Such fusion proteins are useful for antagonizing the TWEAK receptor and for treating diseases or conditions mediated by angiogenesis, such as solid tumors and inflammatory conditions.
(FR) La présente invention concerne des procédés et des compositions ayant trait à des protéines hybrides comprenant des fragments solubles multimériques du récepteur et un domaine d'oligomérisation. De telles protéines hybrides sont utiles en tant qu'antagonistes du récepteur TWEAK et pour le traitement de maladies ou de conditions médiées par l'angiogenèse, telles que des tumeurs solides ou des conditions inflammatoires.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)