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Machine translation
1. (WO2005010044) IL-17 A/F HETEROLOGOUS POLYPEPTIDES AND THERAPEUTIC USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/010044    International Application No.:    PCT/US2004/017581
Publication Date: 03.02.2005 International Filing Date: 02.06.2004
IPC:
A61K 38/00 (2006.01), C07K 14/54 (2006.01), C07K 16/24 (2006.01), G01N 33/68 (2006.01)
Applicants: GENENTECH, INC. [US/US]; 1 DNA Way, South San Francisco, California 94080-4990 (US) (For All Designated States Except US).
ARNOTT, David [US/US]; (US) (For US Only).
GURNEY, Austin [US/US]; (US) (For US Only).
HASS, Philip [US/US]; (US) (For US Only).
LEE, James [US/US]; (US) (For US Only).
WU, Yan [US/US]; (US) (For US Only)
Inventors: ARNOTT, David; (US).
GURNEY, Austin; (US).
HASS, Philip; (US).
LEE, James; (US).
WU, Yan; (US)
Agent: BARNES, Elizabeth; MS 49, 1 DNA Way, South San Francisco, California 94080-4990 (US)
Priority Data:
60/485,599 08.07.2003 US
60/486,457 11.07.2003 US
Title (EN) IL-17 A/F HETEROLOGOUS POLYPEPTIDES AND THERAPEUTIC USES THEREOF
(FR) POLYPEPTIDES HETEROLOGUES IL-17 A/F ET UTILISATION DES POLYPEPTIDES A DES FINS THERAPEUTIQUES
Abstract: front page image
(EN)The present invention is directed to a novel naturally occurring human cytokine that is comprised of a heterodimer of interleukin-17 and interleukin-17F designated herein as interleukin 17A/F (IL-17A/F). Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, specific antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
(FR)La présente invention concerne une nouvelle cytokine humaine d'origine naturelle constituée d'un hétérodimère d'interleukine-17 et d'interleukine-17F, ci-après dénommé interleukine 17A/F (IL-17A/F). L'invention concerne également des vecteurs et des cellules hôtes contenant ces séquences d'acide nucléique; des molécules de polypeptides chimères contenant les polypeptides de l'invention fusionnés aux séquences de polypeptides hétérologues; des anticorps qui se lient spécifiquement aux polypeptides de l'invention; et des méthodes de production des polypeptides de l'invention. L'invention concerne en outre des méthodes de traitement de troubles cartilagineux dégénératifs et d'autres maladies inflammatoires.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)