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1. WO2005010007 - SUBSTITUTED FUROCHROMENES, PREPARATION THEREOF AND THEIR ANTIINFLAMMATORY ACTION

Publication Number WO/2005/010007
Publication Date 03.02.2005
International Application No. PCT/HR2004/000021
International Filing Date 22.07.2004
IPC
C07D 493/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
493Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
CPC
A61P 1/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 11/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
02Nasal agents, e.g. decongestants
A61P 11/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
06Antiasthmatics
A61P 13/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
12of the kidneys
A61P 17/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
Applicants
  • PLIVA- ISTRAZIVACKI INSTITUT D.O.O. [HR]/[HR] (AllExceptUS)
  • MERCEP, Mladen [HR]/[HR] (UsOnly)
  • MESIC, Milan [HR]/[HR] (UsOnly)
  • HRVACIC, Boska [HR]/[HR] (UsOnly)
  • ELENKOV, Ivaylo Jivkov [HR]/[HR] (UsOnly)
  • MALNAR, Ivica [HR]/[HR] (UsOnly)
  • MARKOVIC, Stribor [HR]/[HR] (UsOnly)
  • SIMICIC, Lidija [HR]/[HR] (UsOnly)
  • CEMPUH KLONKAY, Andreja [HR]/[HR] (UsOnly)
  • FILIPOVIC, Anita [HR]/[HR] (UsOnly)
Inventors
  • MERCEP, Mladen
  • MESIC, Milan
  • HRVACIC, Boska
  • ELENKOV, Ivaylo Jivkov
  • MALNAR, Ivica
  • MARKOVIC, Stribor
  • SIMICIC, Lidija
  • CEMPUH KLONKAY, Andreja
  • FILIPOVIC, Anita
Common Representative
  • PLIVA- ISTRAZIVACKI INSTITUT D.O.O.
Priority Data
P20030604A25.07.2003HR
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) SUBSTITUTED FUROCHROMENES, PREPARATION THEREOF AND THEIR ANTIINFLAMMATORY ACTION
(FR) FUROCHROMENES SUBSTITUES, PREPARATION DE CEUX-CI ET LEUR ACTION ANTI-INFLAMMATOIRE
Abstract
(EN) The invention relates to novel compounds of formula (I) including all their tautomers to pharmaceutically acceptable salts and solvates thereof, to processes and reactive intermediates for the preparation thereof; to processes and reactive intermediates for the preparation of compounds of formula (II) including all their stereoisomers and tautomers to the use of the compounds of the formula (II) as suitable precursors for the preparation of the compounds of the formula (I) as well as to use of the compounds of the formula (I) and of the compounds of the formula (II) as therapeutically active agents in the prophylaxis and treatment of asthma and other inflammatory diesases and conditions in humans.
(FR) L'invention concerne de nouveaux composés de formule (I), y compris tous leurs tautomères. L'invention concerne également des sels pharmaceutiquement acceptables et des solvates de ceux-ci. L'invention concerne des procédés et des intermédiaires réactifs pour la préparation de ceux-ci. L'invention concerne des procédés et des intermédiaires réactifs pour la préparation de composés de formule (II), y compris tous leurs stéréisomères et leurs tautomères. L'invention concerne l'utilisation des composés de formule (II) en tant que précurseurs appropriés à la préparation des composés de formule (I), ainsi que l'utilisation des composés de formule (I) et des composés de formule (II) en tant qu'agents thérapeutiquement actifs pour la prophylaxie et pour le traitement de l'asthme et d'autres maladies inflammatoires, ainsi que de troubles chez les humains.
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