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1. (WO2005009408) SUSTAINED RELEASE DOSAGE FORMS OF ANESTHETICS FOR PAIN MANAGEMENT
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2005/009408 International Application No.: PCT/US2003/034763
Publication Date: 03.02.2005 International Filing Date: 31.10.2003
Chapter 2 Demand Filed: 21.01.2005
IPC:
A61K 9/00 (2006.01) ,A61K 47/10 (2006.01) ,A61K 47/14 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
08
containing oxygen
10
Alcohols; Phenols; Salts thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
08
containing oxygen
14
Esters of carboxylic acids
Applicants: ALZA CORPORATION[US/US]; 950 Page Mill Road (P.O. Box 10950) Palo Alto, CA 94303-0802, US
Inventors: CHEN, Guohua; US
PRIEBE, David; US
BANNISTER, Roy; US
HOUSTON, Paul; US
KLEINER, Lothar; US
Agent: ELDERKIN, Dianne, B. ; Woodcock Washburn LLP One Liberty Place 46th Floor Philadelphia, PA 19103, US
Priority Data:
10/606,96925.06.2003US
Title (EN) SUSTAINED RELEASE DOSAGE FORMS OF ANESTHETICS FOR PAIN MANAGEMENT
(FR) FORMES PHARMACEUTIQUES A LIBERATION PROLONGEE D'ANESTHESIANT POUR SOULAGER LA DOULEUR
Abstract:
(EN) Drug delivery systems and kits are provided that release an anesthetic, such as bupivacaine, over a short duration. Methods of administering and preparing such systems are also provided. Drug delivery systems include a short duration gel vehicle and an anesthetic dissolved or dispersed in the gel vehicle. The gel vehicle comprises a low molecular weight bioerodible, biocompatible polymer and a water-immiscible solvent in an amount effective to plasticize the polymer and form a gel with the polymer. In some instances, a component solvent is used along with the water-immiscible solvent. An efficacy ratio, which is one way to measure the efficacy of a delivery system, can be controlled based on, for example, the construction of the gel vehicle to achieve a desired release profile.
(FR) L'invention concerne des systèmes et des trousses d'apport de médicament qui permettent de libérer un anesthésiant tel que la bupivacaïne sur une courte durée. Des procédés d'administration et d'élaboration de tels systèmes sont également prévus. Les systèmes d'apport de médicament comprennent un excipient sous forme de gel de courte durée, et un anesthésiant dissous ou dispersé dans cet excipient. L'excipient gel comprend un polymère de faible poids moléculaire biocompatible et bioérodable, et un solvant non miscible avec l'eau selon une quantité permettant de plastifier le polymère et de former un gel avec celui-ci. Dans certains cas, on utilise un solvant à plusieurs composants avec le solvant non miscible avec l'eau. On peut régler le taux d'efficacité, qui est une façon de mesurer l'efficacité du système d'apport, par exemple selon la construction de l'excipient gel en vue de l'obtention d'un profil de libération voulu.
front page image
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)