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1. (WO2005009119) RAT MODEL OF DIABETIC NEPHROPATHY
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2005/009119 International Application No.: PCT/US2004/023567
Publication Date: 03.02.2005 International Filing Date: 21.07.2004
IPC:
A61K 49/00 (2006.01) ,C12N 15/85 (2006.01)
Applicants: JACOB, Howard, J.[US/US]; US (UsOnly)
ROMAN, Richard, J.[US/US]; US (UsOnly)
NOBREGA, Marcelo[US/US]; US (UsOnly)
MCW RESEARCH FOUNDATION, INC.[US/US]; 8701 Watertown Plank Road Milwaukee, WI 53226, US (AllExceptUS)
Inventors: JACOB, Howard, J.; US
ROMAN, Richard, J.; US
NOBREGA, Marcelo; US
Agent: REN, Zhibin; Quarles & Brady LLP 411 E. Wisconsin Avenue Milwaukee, WI 53202, US
Priority Data:
10/625,87023.07.2003US
Title (EN) RAT MODEL OF DIABETIC NEPHROPATHY
(FR) MODELE DE RAT DE NEPHROPATHIE DIABETIQUE
Abstract: front page image
(EN) A rat model of diabetic nephropathy is disclosed. In another embodiment of the invention, a method of evaluating a test compound’s effect of diabetic nephropathy is disclosed. In one embodiment, this method comprises the steps of (a) exposing the test compound to the rat of claim 1, wherein the rat would develop progressive proteinuria and glomerulosclerosis leading to diabetic nephropathy in the absence of the test compound, and (b) comparing the rat’s development of diabetic nephropathy with a control T2DN mimic rat that has not been exposed to the test compound.
(FR) L'invention porte sur un modèle de rat de néphropathie diabétique. Dans un autre mode de réalisation, l'invention porte sur un procédé d'évaluation des effets d'un composé test de néphropathie diabétique. Dans un mode de réalisation différent, ce procédé consiste (a) à exposer le composé test au rat mentionné à la revendication 1, le rat développant une protéinurie et une glomérolosclérose progressives entraînant la néphropathie diabétique en l'absence du composé test, et (b) à comparer le développement chez le rat de la néphropathie diabétique avec un rat mimétique T2DN de contrôle qui n'a pas été exposé au composé test.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)