WO2004113547 POTENT COMBINATIONS OF MRNA TRANSPORT ELEMENTS

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Publication Number WO/2004/113547

Publication Date 29.12.2004

International Application No. PCT/US2004/015776

International Filing Date 19.05.2004

IPC

CPC

Applicants

THE GOVERNMENT OF THE UNITED STATES, as represented by THE SECRETARY OF HEALTH AND HUMAN SERVICES [US]/[US] (AllExceptUS)
FELBER, Barbara [US]/[US] (UsOnly)
SMULEVITCH, Sergey, V. (UsOnly)
PAVLAKIS, George [US]/[US] (UsOnly)

Inventors

Agents

Priority Data

60/471,988		19.05.2003		US
60/472,223		20.05.2003		US

Publication Language English (en)

Filing Language English (EN)

Designated States

Title

(EN) POTENT COMBINATIONS OF MRNA TRANSPORT ELEMENTS

(FR) COMBINAISONS PUISSANTES D'ELEMENTS DE TRANSPORT DE L'ARNM

Abstract

(EN) This invention provides expression vectors that comprise a combination of RNA transport elements that improve expression.

(FR) L'invention concerne des vecteurs d'expression comprenant une combinaison d'éléments de transport d'ARNm améliorant l'expression.

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39	Medicinal preparations containing antigens or antibodies

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
14	Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005	from viruses
08	RNA viruses
15	Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus
155	Lentiviridae, e.g. human immunodeficiency virus (HIV), visna-maedi virus, equine infectious anaemia virus
16	HIV-1

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N	MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15	Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09	Recombinant DNA-technology
63	Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N	MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15	Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09	Recombinant DNA-technology
63	Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79	Vectors or expression systems specially adapted for eukaryotic hosts
85	for animal cells

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N	MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15	Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09	Recombinant DNA-technology
63	Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79	Vectors or expression systems specially adapted for eukaryotic hosts
85	for animal cells
86	Viral vectors
867	Retroviral vectors

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N	MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2740	Reverse Transcribing RNA Viruses
00011	Reverse Transcribing RNA Viruses
10011	Retroviridae
16011	Human Immunodeficiency Virus, HIV
16111	concerning HIV env
16122	New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N	MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2740	Reverse Transcribing RNA Viruses
00011	Reverse Transcribing RNA Viruses
10011	Retroviridae
16011	Human Immunodeficiency Virus, HIV
16211	concerning HIV gagpol
16222	New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes