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1. WO2004112746 - CONTROLLED RELEASE-DRUG DELIVERY SYSTEM FOR ORAL ADMINISTRATION

Publication Number WO/2004/112746
Publication Date 29.12.2004
International Application No. PCT/KR2004/001437
International Filing Date 16.06.2004
Chapter 2 Demand Filed 24.01.2005
IPC
A61K 9/50 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules
CPC
A61K 9/5026
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules ; having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
5005Wall or coating material
5021Organic macromolecular compounds
5026obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
A61K 9/5042
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules ; having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
5005Wall or coating material
5021Organic macromolecular compounds
5036Polysaccharides, e.g. gums, alginate; Cyclodextrin
5042Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
A61K 9/5047
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules ; having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
5005Wall or coating material
5021Organic macromolecular compounds
5036Polysaccharides, e.g. gums, alginate; Cyclodextrin
5042Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
5047Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
A61K 9/5078
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules ; having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
5073having two or more different coatings optionally including drug-containing subcoatings
5078with drug-free core
Applicants
  • KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY [KR]/[KR] (AllExceptUS)
  • LEE, Hai Bang [KR]/[KR] (UsOnly)
  • CHO, Sun Hang [KR]/[KR] (UsOnly)
  • KHANG, Gilson [KR]/[KR] (UsOnly)
  • JEONG, Sang Young [KR]/[KR] (UsOnly)
  • KANG, Bok Ki [KR]/[KR] (UsOnly)
  • SEO, Kwang Su [KR]/[KR] (UsOnly)
  • KIM, Moon Suk [KR]/[KR] (UsOnly)
  • CHON, Se Kang [KR]/[KR] (UsOnly)
Inventors
  • LEE, Hai Bang
  • CHO, Sun Hang
  • KHANG, Gilson
  • JEONG, Sang Young
  • KANG, Bok Ki
  • SEO, Kwang Su
  • KIM, Moon Suk
  • CHON, Se Kang
Agents
  • YOU ME PATENT & LAW FIRM
Priority Data
10-2003-004201526.06.2003KR
10-2003-005791821.08.2003KR
Publication Language English (en)
Filing Language Korean (KO)
Designated States
Title
(EN) CONTROLLED RELEASE-DRUG DELIVERY SYSTEM FOR ORAL ADMINISTRATION
(FR) SYSTEME DE RELARGAGE DE MEDICAMENT A LIBERATION LENTE DESTINE A ETRE ADMINISTRE PAR VOIE ORALE
Abstract
(EN) The present invention relates to a controlled-release drug delivery system for oral administration and a composition for forming a controlled-release porous membrane employed in the system. The controlled-release drug delivery system for oral administration of the present invention comprises a core containing a pharmaceutically active ingredient; and a controlled-release porous membrane coated on the outer surface of the core comprising at least one film formation material selected from the group consisting of a cellulose based compound, polymethacrylate, an acetate based compound, polyamide, polyurethane and sulfonated polystyrene. The controlled-release drug delivery system for oral administration according to the present invention can provide an effective and consistent drug release in gastrointestinal tracts because the release rate of the drugs can be controlled. Also, the timing of drug release can be controlled by varying the thickness of the porous membrane, composition of the membrane material, amount of the plasticizer and amount of the vehicles. And, preparation of the controlled-release formulation becomes simple and cost-effective because a small amount of the porous membrane is coated on a conventional tablet or granule. In addition, since the membrane is highly stable, a controlled-release formulation for oral administration not affected by temperature or humidity can be produced in large quantities.
(FR) L'invention concerne un système de relargage de médicament à libération lente destiné à être administré par voie orale et une composition utilisée pour la formation d'une membrane poreuse à libération lente utilisée dans ce système. Ce système de relargage de médicament à libération lente destiné à être administré par voie orale comprend un noyau contenant un ingrédient actif au plan pharmaceutique ; et une membrane poreuse à libération lente appliquée sur la surface extérieure du noyau, comprenant au moins une matière filmogène choisie dans le groupe constitué d'un composé à base de cellulose, du polyméthacrylate, d'un composé à base d'acétate, du polyamide, du polyuréthanne et du polystyrène sulfoné. Le système de relargage de médicament à libération lente destiné à être administré par voie orale peut assurer une libération efficace et régulière dans le tractus-gastrointestinal car le débit de libération des médicaments peut être régulé. Ainsi, la temporisation de la libération de médicament peut être modulée par la modification de l'épaisseur de la membrane poreuse, de la composition de la matière constitutive de la membrane, de la quantité de plastifiant et du volume des véhicules. La préparation du produit formulé à libération lente devient simple et économique car une petite quantité de la membrane poreuse recouvre un comprimé ou un granule classique. Par ailleurs, étant donné que la membrane est très stable, un produit formulé à libération lente destiné à être administré par voie orale, insensible à la température ou à l'humidité, peut être produit en grandes quantités.
Related patent documents
PH12005502110This application is not viewable in PATENTSCOPE because the national phase entry has not been published yet or the national entry is issued from a country that does not share data with WIPO or there is a formatting issue or an unavailability of the application.
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