WO2004108726 2-SUBSTITUTED PHENYL-5,7-DIALKYL-3,7-DIHYDROPYRROLE [2,3-d] PYRIMIDINE-4-ONE DERIVATIVES, THE PREPARATION AND THE PHARMACEUTICAL USE THEREOF

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Publication Number WO/2004/108726

Publication Date 16.12.2004

International Application No. PCT/CN2004/000487

International Filing Date 14.05.2004

Chapter 2 Demand Filed 30.11.2004

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CPC

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Applicants

TIANJIN TASLY GROUP CO., LTD. [CN]/[CN] (AllExceptUS)
TIANJIN NORTH PHARMA SCI-TECH CO., LTD [CN]/[CN] (AllExceptUS)
WANG, Yongfeng [CN]/[CN] (UsOnly)
ZHAO, Kejun [CN]/[CN] (UsOnly)

Inventors

WANG, Yongfeng
ZHAO, Kejun

Agents

CCPIT PATENT AND TRADEMARK LAW OFFICE

Priority Data

03142399.X

06.06.2003

Publication Language Chinese (zh)

Filing Language Chinese (ZH)

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Title

(EN) 2-SUBSTITUTED PHENYL-5,7-DIALKYL-3,7-DIHYDROPYRROLE [2,3-d] PYRIMIDINE-4-ONE DERIVATIVES, THE PREPARATION AND THE PHARMACEUTICAL USE THEREOF

(FR) DERIVES PHENYL-5,7-DIALALKYL-3,7-DIHYDROPYRROL[2,3-D]PYRIMIDINE-4-ONE SUBSTITUES EN POSITION 2, LEUR PREPARATION ET LEUR UTILISATION EN PHARMACIE

Abstract

(EN) The invention relates to the compounds of formula 1, their preparation and the pharmaceutical compositions containing the compounds. The invention also relates to the use of the compounds of formula I in preparing medicines, which can treat sexual dysfunction of animals including human (male and female), especially erectile dysfunction of male and the diseases in which the function of phospholipase 5 (cGMP PDE5) is involved.

(FR) L'invention concerne des composés correspondant à la formule (I), leur préparation et les compositions pharmaceutiques les contenant. L'invention concerne également l'utilisation de ces composés dans la préparation de médicament destiné à traiter une dysfonction sexuelle chez les animaux (mâles et femelles) et chez l'homme ou la femme, en particulier une dysérection et les maladies dans lesquelles la fonction de la phospholipase 5 (cGMP PDE5) est impliquée.

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
C	ACYCLIC OR CARBOCYCLIC COMPOUNDS
51	Preparation of carboxylic acids or their salts, halides, or anhydrides

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
487	Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02	in which the condensed system contains two hetero rings
04	Ortho-condensed systems

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
C	ACYCLIC OR CARBOCYCLIC COMPOUNDS
51	Preparation of carboxylic acids or their salts, halides, or anhydrides

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
487	Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02	in which the condensed system contains two hetero rings
04	Ortho-condensed systems

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1	Drugs for disorders of the alimentary tract or the digestive system

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1. WO2004108726 - 2-SUBSTITUTED PHENYL-5,7-DIALKYL-3,7-DIHYDROPYRROLE [2,3-d] PYRIMIDINE-4-ONE DERIVATIVES, THE PREPARATION AND THE PHARMACEUTICAL USE THEREOF

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
C	ACYCLIC OR CARBOCYCLIC COMPOUNDS
65	Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
21	containing ether groups, groups, groups, or groups