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1. WO2004108726 - 2-SUBSTITUTED PHENYL-5,7-DIALKYL-3,7-DIHYDROPYRROLE [2,3-d] PYRIMIDINE-4-ONE DERIVATIVES, THE PREPARATION AND THE PHARMACEUTICAL USE THEREOF

Publication Number WO/2004/108726
Publication Date 16.12.2004
International Application No. PCT/CN2004/000487
International Filing Date 14.05.2004
Chapter 2 Demand Filed 30.11.2004
IPC
C07C 51/00 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
51Preparation of carboxylic acids or their salts, halides, or anhydrides
C07D 487/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
CPC
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 1/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
A61P 11/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
06Antiasthmatics
A61P 13/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
02of urine or of the urinary tract, e.g. urine acidifiers
A61P 13/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
08of the prostate
A61P 13/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
10of the bladder
Applicants
  • TIANJIN TASLY GROUP CO., LTD. [CN]/[CN] (AllExceptUS)
  • TIANJIN NORTH PHARMA SCI-TECH CO., LTD [CN]/[CN] (AllExceptUS)
  • WANG, Yongfeng [CN]/[CN] (UsOnly)
  • ZHAO, Kejun [CN]/[CN] (UsOnly)
Inventors
  • WANG, Yongfeng
  • ZHAO, Kejun
Agents
  • CCPIT PATENT AND TRADEMARK LAW OFFICE
Priority Data
03142399.X06.06.2003CN
Publication Language Chinese (zh)
Filing Language Chinese (ZH)
Designated States
Title
(EN) 2-SUBSTITUTED PHENYL-5,7-DIALKYL-3,7-DIHYDROPYRROLE [2,3-d] PYRIMIDINE-4-ONE DERIVATIVES, THE PREPARATION AND THE PHARMACEUTICAL USE THEREOF
(FR) DERIVES PHENYL-5,7-DIALALKYL-3,7-DIHYDROPYRROL[2,3-D]PYRIMIDINE-4-ONE SUBSTITUES EN POSITION 2, LEUR PREPARATION ET LEUR UTILISATION EN PHARMACIE
Abstract
(EN) The invention relates to the compounds of formula 1, their preparation and the pharmaceutical compositions containing the compounds. The invention also relates to the use of the compounds of formula I in preparing medicines, which can treat sexual dysfunction of animals including human (male and female), especially erectile dysfunction of male and the diseases in which the function of phospholipase 5 (cGMP PDE5) is involved.
(FR) L'invention concerne des composés correspondant à la formule (I), leur préparation et les compositions pharmaceutiques les contenant. L'invention concerne également l'utilisation de ces composés dans la préparation de médicament destiné à traiter une dysfonction sexuelle chez les animaux (mâles et femelles) et chez l'homme ou la femme, en particulier une dysérection et les maladies dans lesquelles la fonction de la phospholipase 5 (cGMP PDE5) est impliquée.
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