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1. WO2004106377 - METHODS FOR PRODUCING ANTIBODIES

Publication Number WO/2004/106377
Publication Date 09.12.2004
International Application No. PCT/GB2004/002226
International Filing Date 24.05.2004
IPC
C07K 16/00 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
C07K 16/24 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
24against cytokines, lymphokines or interferons
CPC
C07K 16/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
C07K 16/244
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
24against cytokines, lymphokines or interferons
244Interleukins [IL]
Applicants
  • CELLTECH R & D LIMITED [GB]/[GB] (AllExceptUS)
  • LAWSON, Alastair David Griffiths [GB]/[GB] (UsOnly)
  • LIGHTWOOD, Daniel John [GB]/[GB] (UsOnly)
Inventors
  • LAWSON, Alastair David Griffiths
  • LIGHTWOOD, Daniel John
Agents
  • THOMPSON, John
Priority Data
0312481.530.05.2003GB
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHODS FOR PRODUCING ANTIBODIES
(FR) METHODES DE PRODUCTION D'ANTICORPS
Abstract
(EN) The invention relates to a method of obtaining an antibody with a desired function, the method comprising: a) bringing a population of B cells into contact with a capturing agent; b) separating the captured B cells from the uncaptured B cells; c) culturing a plurality of captured B cells wherein said B cells have not been sorted into single B cells immediately prior to culturing; d) screening a plurality of the cultured cells to identify cells capable of producing an antibody with the desired function; and e) obtaining the desired antibody therefrom.
(FR) L'invention concerne une méthode d'obtention d'un anticorps ayant une fonction voulue, la méthode consistant : (a) à mettre une population de lymphocytes B en contact avec un agent de capture ; (b) à séparer les lymphocytes B capturés des lymphocytes B non capturés ; (c) à mettre en culture une pluralité de lymphocytes B capturés dans laquelle lesdits lymphocytes B non pas été triés en lymphocytes B individuels immédiatement avant la mise en culture ; (d) à cribler une pluralité des cellules de mise en culture afin d'identifier des cellules capables de produire un anticorps ayant la fonction voulue ; et (e) à obtenir l'anticorps voulu à partir desdites cellules.
Related patent documents
US2007009959This application is not viewable in PATENTSCOPE because the national phase entry has not been published yet or the national entry is issued from a country that does not share data with WIPO or there is a formatting issue or an unavailability of the application.
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