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1. (WO2004106356) FUNCTIONALIZED NUCLEOTIDE DERIVATIVES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2004/106356 International Application No.: PCT/DK2004/000372
Publication Date: 09.12.2004 International Filing Date: 27.05.2004
IPC:
C07H 19/06 (2006.01) ,C07H 19/10 (2006.01) ,C07H 19/16 (2006.01) ,C07H 19/20 (2006.01) ,C07H 21/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19
Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02
sharing nitrogen
04
Heterocyclic radicals containing only nitrogen as ring hetero atom
06
Pyrimidine radicals
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19
Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02
sharing nitrogen
04
Heterocyclic radicals containing only nitrogen as ring hetero atom
06
Pyrimidine radicals
10
with the saccharide radical being esterified by phosphoric or polyphosphoric acids
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19
Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02
sharing nitrogen
04
Heterocyclic radicals containing only nitrogen as ring hetero atom
16
Purine radicals
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19
Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02
sharing nitrogen
04
Heterocyclic radicals containing only nitrogen as ring hetero atom
16
Purine radicals
20
with the saccharide radical being esterified by phosphoric or polyphosphoric acids
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Applicants:
WENGEL, Jesper [DK/DK]; DK (UsOnly)
BRYLD, Torsten [DK/US]; US (UsOnly)
SYDDANSK UNIVERSITET [DK/DK]; Campusvej 55 DK-5230 Odense Ø, DK (AllExceptUS)
Inventors:
WENGEL, Jesper; DK
BRYLD, Torsten; US
Agent:
PLOUGMANN & VINGTOFT A/S; Sundkrogsgade 9 P.O. Box 831 DK-2100 Copenhagen Ø, DK
Priority Data:
PA 2003 0080427.05.2003DK
Title (EN) FUNCTIONALIZED NUCLEOTIDE DERIVATIVES
(FR) DERIVES DE NUCLEOTIDES FONCTIONNALISES
Abstract:
(EN) A nucleotide derivative is disclosed, which in its 4’ and/or 5’ position on the sugar moiety is substituted with a group comprising a non-aromatic cyclid group comprising at least one nitrogen atom, said cyclid group optionally being substituted. The nucleotide monomer induces increased thermal stability of RNA:DNA, RNA:RNA or DNA:DNA duplexes, if said RNA and/or DNA strand comprises at least one said monomer. The nucleotides and oligonucleotides comprising at least one of said nucleotides can be used in therapy (such as antisense or antigene therapy) and in methods for synthesising polynucleotides (e.g. as a primer). The nucleotide derivative may also be used in a medicament. Further, the use of the nucleotide derivative for the preparation of a medicament for the treatment of diseases or disorders is also disclosed.
(FR) L'invention concerne un dérivé de nucléotide qui, dans sa position 4' et/ou 5' sur la fraction de sucre est remplacé par un groupe contenant un groupe cyclique non aromatique contenant au moins un atome d'azote, ledit groupe cyclique étant facultativement substitué. Le monomère nucléotidique induit une stabilité thermique accrue de duplex d'ARN: ADN, ARN: ARN ou d'ADN: ADN, si ledit brin d'ARN et/ou d'ADN contient au moins ledit monomère. Les nucléotides et les oligonucléotides contenant au moins un desdits nucléotides peuvent être utilisés en thérapie (par exemple en thérapie antisens ou antigénique) et dans des méthodes de synthèse de polynucléotides (par exemple en tant qu'amorce). Le dérivé de nucléotides peut aussi être utilisé dans un médicament. En outre, est également décrite l'utilisation du dérivé de nucléotides dans la préparation d'un médicament pour le traitement de pathologies ou de troubles.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)