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1. WO2004106276 - CONDENSED RING COMPOUND

Publication Number WO/2004/106276
Publication Date 09.12.2004
International Application No. PCT/JP2004/007770
International Filing Date 28.05.2004
IPC
C07C 59/64 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
59Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O-metal, -CHO, keto, ether, groups, groups, or groups
40Unsaturated compounds
58containing ether groups, groups, groups, or groups
64containing six-membered aromatic rings
C07C 59/68 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
59Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O-metal, -CHO, keto, ether, groups, groups, or groups
40Unsaturated compounds
58containing ether groups, groups, groups, or groups
64containing six-membered aromatic rings
66the non-carboxylic part of the ether containing six-membered aromatic rings
68the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
C07C 59/72 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
59Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O-metal, -CHO, keto, ether, groups, groups, or groups
40Unsaturated compounds
58containing ether groups, groups, groups, or groups
72containing six-membered aromatic rings and other rings
C07C 69/734 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
69Esters of carboxylic acids; Esters of carbonic or haloformic acids
66Esters of carboxylic acids having esterified carboxyl groups bound to acyclic carbon atoms and having any of the groups OH, O-metal, -CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
73of unsaturated acids
734Ethers
CPC
A61P 3/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
C07C 2601/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
2601Systems containing only non-condensed rings
02with a three-membered ring
C07C 2602/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
2602Systems containing two condensed rings
02the rings having only two atoms in common
04One of the condensed rings being a six-membered aromatic ring
10the other ring being six-membered, e.g. tetraline
C07C 59/64
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
59Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
40Unsaturated compounds
58containing ether groups, groups, groups, or groups
64containing six-membered aromatic rings
C07C 59/68
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
59Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
40Unsaturated compounds
58containing ether groups, groups, groups, or groups
64containing six-membered aromatic rings
66the non-carboxylic part of the ether containing six-membered aromatic rings
68the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
C07C 59/72
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
59Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
40Unsaturated compounds
58containing ether groups, groups, groups, or groups
72containing six-membered aromatic rings and other rings
Applicants
  • TAKEDA PHARMACEUTICAL COMPANY LIMITED [JP]/[JP] (AllExceptUS)
  • 安間 常雄 YASUMA, Tsuneo [JP]/[JP] (UsOnly)
  • 根来 伸行 NEGORO, Nobuyuki [JP]/[JP] (UsOnly)
  • 深津 考司 FUKATSU, Kohji [JP]/[JP] (UsOnly)
Inventors
  • 安間 常雄 YASUMA, Tsuneo
  • 根来 伸行 NEGORO, Nobuyuki
  • 深津 考司 FUKATSU, Kohji
Agents
  • 高島 一 TAKASHIMA, Hajime
Priority Data
2003-15398630.05.2003JP
2004-13914407.05.2004JP
Publication Language Japanese (ja)
Filing Language Japanese (JA)
Designated States
Title
(EN) CONDENSED RING COMPOUND
(FR) COMPOSE CYCLIQUE CONDENSE
(JA) 縮合環化合物
Abstract
(EN) A novel condensed ring compound having the activity of regulating GPR40-receptor function and being useful as an insulin secretion promoter or as a preventive/therapeutic agent for diabetes mellitus, etc. More specifically, a condensed ring compound of the formula: (I) [wherein: Ar is a substituted or unsubstituted cyclic group; ring A is a further substituted or unsubstituted ring (provided that the ring is none of thiazole, oxazole, imidazole and pyrazole); each of Xa and Xb independently is a bond or a spacer of 1 to 5 main chain atoms; Xc is O, S, SO or SO2; is or ; ring B is a 5 to 7-membered ring; Xd is a bond, CH or CH2; ...... is a single bond when Xd is a bond or CH2, and a double bond when Xd is CH; and R1 is a substituted or unsubstituted hydroxyl] or a salt thereof.
(FR) Nouveau composé cyclique condensé possédant une activité de régulation de la fonction du récepteur de GPR40 et utile en tant que promoteur de sécrétion d'insuline ou qu'agent prophylactique/thérapeutique contre le diabète sucré. Plus particulièrement, composé cyclique condensé représenté par la formule (I) dans laquelle Ar représente un groupe cyclique substitué ou insubstitué ; le noyau A représente un autre noyau substitué ou insubstitué, dans la mesure où ce noyau ne représente pas thiazole, oxazole, imidazole ou pyrazole ; chacun de Xa et Xb indépendamment représente une liaison ou un espaceur de 0 à 5 atomes de chaîne principale ; Xc représente O, S, SO ou SO2 ; le noyau B est un noyau à 5 à 7 éléments ; Xd représente une liaison, CH ou CH2 ; représente une liaison simple quand Xd représente une liaison ou CH2, et une liaison double quand Xd représente CH ; et R1 représente hydroxyle substitué ou insubstitué, l'invention concernant également un sel dudit composé.
(JA) not available
Related patent documents
US2006258722This application is not viewable in PATENTSCOPE because the national phase entry has not been published yet or the national entry is issued from a country that does not share data with WIPO or there is a formatting issue or an unavailability of the application.
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