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Machine translation
1. (WO2004102199) METHOD FOR SELECTING AND PRODUCING VACCINE COMPONENTS AND VACCINES BASED THEREON
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/102199    International Application No.:    PCT/NL2004/000338
Publication Date: 25.11.2004 International Filing Date: 17.05.2004
IPC:
C07K 16/12 (2006.01), G01N 33/569 (2006.01)
Applicants: ERASMUS UNIVERSITAIR MEDISCH CENTRUM [NL/NL]; Dr. Molewaterplein 40-60, NL-3015 GD Rotterdam (NL) (For All Designated States Except US).
LEENHOUTS, Cornelis, Johannes [NL/NL]; (NL) (For US Only).
DE GROOT, Ronald [NL/NL]; (NL) (For US Only).
HERMANS, Peter, Wilhelmus, Maria [NL/NL]; (NL) (For US Only)
Inventors: LEENHOUTS, Cornelis, Johannes; (NL).
DE GROOT, Ronald; (NL).
HERMANS, Peter, Wilhelmus, Maria; (NL)
Agent: WINCKELS, J., H., F.; Vereenigde, Johan de Wittlaan 7, NL-2517 JR Den Haag (NL)
Priority Data:
03076492.2 16.05.2003 EP
Title (EN) METHOD FOR SELECTING AND PRODUCING VACCINE COMPONENTS AND VACCINES BASED THEREON
(FR) PROCEDE DE SELECTION ET DE PRODUCTION DE COMPOSANTS DE VACCINS, ET VACCINS DERIVES DE CEUX-CI
Abstract: front page image
(EN)The invention relates to the field of biology, more specifically to the field of immunology and microbiology. The invention further relates to the field of vaccines against microbial infections and especially bacterial vaccines, in particular to pneumococcal vaccines. More in particular, the invention relates to means and methods to identify, select and isolate a vaccine component for passive and/or active immunisation against a microorganism that can be killed by opsonophagocytic cells. The invention relates to a method to identify an opsonophagocytosis inducing antigen as a vaccine component for immunisation against a microorganism. The invention describes three pneumococcal proteins SlrA, IgA1 proteinase, and PsaA, and their use as a vaccine component with or without PpmA. The invention also discloses the use of antibodies against said proteins for passive immunization and diagnosis.
(FR)L'invention concerne le domaine de la biologie et, plus spécifiquement, le domaine de l'immunologie et de la microbiologie. L'invention concerne en outre le domaine des vaccins contre des infections microbiennes, notamment des vaccins bactériens et, en particulier, des vaccins antipneumococciques. Plus particulièrement, l'invention concerne des moyens et des procédés permettant d'identifier, de sélectionner et d'isoler un composant de vaccin pour une immunisation passive et/ou active contre un micro-organisme qui peut être tué par des cellules opsonophagocytiques. L'invention concerne un procédé permettant d'identifier un antigène occasionnant une opsonophagocytose, en tant que composant d'un vaccin, en vue d'une immunisation contre un micro-organisme. L'invention décrit trois protéines pneumococciques S1rA, protéinase IgA1 et PsaA, et leur utilisation comme composant de vaccin avec, ou sans PpmA. Enfin, l'invention concerne l'utilisation d'anticorps contre lesdites protéines, en vue de l'immunisation passive et du diagnostic.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)