WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2004101781) CRYSTAL STRUCTURE OF HUMAN CORONAVIRUS 229E MAIN PROTEINASE, AND USES THEREOF FOR DEVELOPING SARS INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/101781    International Application No.:    PCT/EP2004/005109
Publication Date: 25.11.2004 International Filing Date: 13.05.2004
IPC:
C07K 14/165 (2006.01), C12N 9/50 (2006.01)
Applicants: UNIVERSITÄT ZU LÜBECK [DE/DE]; Ratzeburger Allee 160, 23538 Lübeck (DE) (For All Designated States Except US).
HILGENFELD, Rolf [DE/DE]; (DE) (For US Only).
ANAND, Kanchan [--/DE]; (DE) (For US Only).
ZIEBUHR, John [DE/DE]; (DE) (For US Only).
MESTERS, Jeroen, R. [DE/DE]; (DE) (For US Only).
WADHWANI, Parvesh [--/DE]; (DE) (For US Only)
Inventors: HILGENFELD, Rolf; (DE).
ANAND, Kanchan; (DE).
ZIEBUHR, John; (DE).
MESTERS, Jeroen, R.; (DE).
WADHWANI, Parvesh; (DE)
Agent: BIEHL, Christian; Boehmert & Boehmert, Niemannsweg 133, 24105 Kiel (DE)
Priority Data:
60/469,818 13.05.2003 US
Title (EN) CRYSTAL STRUCTURE OF HUMAN CORONAVIRUS 229E MAIN PROTEINASE, AND USES THEREOF FOR DEVELOPING SARS INHIBITORS
(FR) STRUCTURE CRISTALLINE DE LA PROTEINASE PRINCIPALE 229E DES CORONAVIRUS HUMAINS ET UTILISATIONS DE CETTE DERNIERE POUR DEVELOPPER DES INHIBITEURS DU SRAS
Abstract: front page image
(EN)The invention relates to SARS inhibitors. Human coronaviruses are major causes of upper respiratory tract illness in humans, in particular, the common cold. Recent investigations have shown that a novel coronavirus causes the Severe Acute Respiratory Syndrome (SARS), a disease that is characterized by high fever, malaise, rigor, headache, non-productive cough or dyspnea and which is rapidly spreading. Within the scope of the invention, based on the structural analysis of the binding mode of the SARS Mpro enzyme a group of prototype inhibitors is provided that acts as suitable drugs targeting a majority of viral infections of the respiratory tract, including SARS.
(FR)L'invention concerne des inhibiteurs du syndrome respiratoire aigu sévère (SRAS). Les coronavirus humains sont des causes majeures de l'affection des voies respiratoires supérieures chez les humains, en particulier le rhume. De récentes enquêtes ont révélé qu'un nouveau coronavirus est à l'origine du syndrome respiratoire aigu sévère (SRAS), une maladie à propagation rapide caractérisée par une forte fièvre, un malaise, une rigidité, des maux de tête, une toux non productive ou une dyspnée. Selon la présente invention, l'analyse structurelle du mode de liaison de l'enzyme SRAS Mpro a permis de développer un groupe d'inhibiteurs prototypes agissant comme des médicaments appropriés ciblant une majorité d'infections virales des voies respiratoires, notamment le SRAS.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)