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1. (WO2004101745) NOVEL REGULATORY MECHANISMS OF NF-kappaB
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/101745    International Application No.:    PCT/US2004/014155
Publication Date: 25.11.2004 International Filing Date: 07.05.2004
IPC:
G01N 33/53 (2006.01), G01N 33/567 (2006.01)
Applicants: BETH ISRAEL DEACONESS MEDICAL CENTER, INC. [US/US]; 330 Brookline Avenue, Boston, MA 02215 (US) (For All Designated States Except US).
RYO, Akihide [KR/JP]; (JP) (For US Only).
LU, Kun, Ping [CN/US]; (US) (For US Only)
Inventors: RYO, Akihide; (JP).
LU, Kun, Ping; (US)
Agent: HANLEY, Elizabeth, A.; Lahive & Cockfield, LLP, 28 State Street, Boston, MA 02109 (US)
Priority Data:
60/469,542 08.05.2003 US
60/490,109 25.07.2003 US
Title (EN) NOVEL REGULATORY MECHANISMS OF NF-kappaB
(FR) MECANISMES DE REGULATION DE NF-KAPPAB
Abstract: front page image
(EN)The instant invention pertains to the discovery of two novel regulatory mechanisms of NF-kB. The instant invention demonstrates that NF-kB is regulated by PinI-catalyzed prolyl isomerization and ubiquitin-mediated proteolysis of p65. Accordingly, the instant invention provides methods for regulating NF-kB, and diseases and disorders associated with NF-kB. Further, the invention provides compositions capable of modulating the activity or expression of NF-kB, Pinl, and/or the proteolysis of p65.
(FR)L'invention concerne deux mécanismes de régulation de NF-kB. La régulation est assurée par isomération de prolyle catalysée par PinI et protéolyse de p65 à médiation par ubiquitine. On décrit également des procédés de régulation de NF-kB, et de régulation pour les maladies et les troubles associés au NF-kB. On décrit enfin des compositions capables de moduler l'activité ou l'expression de NF-kB, Pinl, et/ou la protéolyse de p65.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)