WO2004101586 NOVEL 14 AND 15 MEMBERED-RING COMPOUNDS

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Publication Number WO/2004/101586

Publication Date 25.11.2004

International Application No. PCT/EP2004/005082

International Filing Date 11.05.2004

IPC

CPC

Applicants

GLAXO GROUP LIMITED [GB]/[GB] (AllExceptUS)
PLIVA - ISTRAZIVACKI INSTITUT D.O.O. [HR]/[HR] (AllExceptUS)
ALIHODZIC, Sulejman [HR]/[HR] (UsOnly)
FORREST, Andrew, Keith [GB]/[GB] (UsOnly)
JARVEST, Richard, Lewis [GB]/[GB] (UsOnly)
LAZAREVSKI, Gorjana [HR]/[HR] (UsOnly)
PAVLOVIC, Drazen [HR]/[HR] (UsOnly)

Inventors

ALIHODZIC, Sulejman
FORREST, Andrew, Keith
JARVEST, Richard, Lewis
LAZAREVSKI, Gorjana
PAVLOVIC, Drazen

Agents

GLADWIN, Amanda, Rachel

Priority Data

0310986.5

13.05.2003

Publication Language English (en)

Filing Language English (EN)

Designated States

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Title

(EN) NOVEL 14 AND 15 MEMBERED-RING COMPOUNDS

(FR) NOUVEAU COMPOSES A CYCLE RAMIFIE EN 14 ET 15.

Abstract

(EN) The present invention relates to 14- or 15-membered macrolides substituted at the 4' position of formula (I) and pharmaceutically acceptable derivatives thereof, to processes for their preparation and their use in therapy or prophylaxis of systemic or topical microbial infections in a human or animal body.

(FR) La présente invention concerne des macrolides ramifiés en 14 et 15 substitués en position 4'', représentés par la formule (I) et des dérivés de ceux-ci répondant aux normes pharmaceutiques, et des processus de préparation et d'utilisation de ceux-ci dans la thérapie et la prophylaxie d'infections microbiennes topiques ou systémiques chez l'homme ou chez l'animal.

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
70	Carbohydrates; Sugars; Derivatives thereof
7042	Compounds having saccharide radicals and heterocyclic rings
7048	having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
H	SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
17	Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
04	Heterocyclic radicals containing only oxygen as ring hetero atoms
08	Hetero rings containing eight or more ring members, e.g. erythromycins

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
70	Carbohydrates; Sugars; Derivatives thereof
7042	Compounds having saccharide radicals and heterocyclic rings
7048	having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
H	SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
17	Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
04	Heterocyclic radicals containing only oxygen as ring hetero atoms
08	Hetero rings containing eight or more ring members, e.g. erythromycins

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
70	Carbohydrates; Sugars; Derivatives thereof
7042	Compounds having saccharide radicals and heterocyclic rings
7048	having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin ; digitoxin or digoxin

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1. WO2004101586 - NOVEL 14 AND 15 MEMBERED-RING COMPOUNDS

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31	Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04	Antibacterial agents