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Machine translation
1. (WO2004100888) N-THIOLATED AZETIDINONES AND ANTI-CANCER USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/100888    International Application No.:    PCT/US2004/014460
Publication Date: 25.11.2004 International Filing Date: 06.05.2004
IPC:
C07D 205/08 (2006.01), C07D 491/04 (2006.01)
Applicants: UNIVERSITY OF SOUTH FLORIDA [US/US]; 4202 E. Fowler Avenue, FAO 126, Tampa, FL 33620 (US) (For All Designated States Except US).
DOU, Q., Ping [US/US]; (US) (For US Only).
TUROS, Edward [US/US]; (US) (For US Only).
SMITH, David, M. [US/US]; (US) (For US Only)
Inventors: DOU, Q., Ping; (US).
TUROS, Edward; (US).
SMITH, David, M.; (US)
Agent: PACE, Doran, R.; Saliwanchik, Lloyd & Saliwanchik, A Professional Association, PO Box 142950, Gainesville, FL 32614-2950 (US)
Priority Data:
10/431,113 06.05.2003 US
Title (EN) N-THIOLATED AZETIDINONES AND ANTI-CANCER USE THEREOF
(FR) PROCEDES POUR PREVENIR ET TRAITER LE CANCER AU MOYEN DE COMPOSES A BASE DE BETA-LACTAME N-THIOLE ET DE CERTAINS DE LEURS ANALOGUES
Abstract: front page image
(EN)The subject invention concerns N-thiolated &bgr;-lactam compounds, their analogs and pharmaceutically acceptable salts, esters and amides thereof. The subject invention also concerns methods for inducing tumor cell death or inhibiting tumor cell proliferation, and methods for inducing DNA damage, inhibiting DNA replication, activating p38 MAP kinase, or activating caspase cascade activation, or releasing cytochrome C from mitochondria into the cytoplasm in a tumor cell. Methods for treating cancer using N-thiolated &bgr;-lactam compounds, as well as pharmaceutical compositions comprising the same are further disclosed.
(FR)La présente invention concerne des composés à base de $g(b)-lactame N-thiolé, de leurs analogues et de certains de leurs sels, esters et amides pharmaceutiquement admis. L'invention concerne également des procédés permettant d'induire la mort des cellules tumorales ou d'inhiber la prolifération des cellules tumorales, et des procédés pour induire des atteintes à l'ADN, inhiber la réplication d'ADN, activer la MAP-kinase p38, d'activer l'activation de la cascade de caspases, ou encore de libérer le cytochrome C des mitochondries dans le cytoplasme d'une cellule tumorale. L'invention concerne enfin des procédés pour traiter le cancer au moyen de composés à base de $g(b)-lactame N-thiolé, ainsi que des compositions pharmaceutiques en contenant.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)