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1. (WO2004100885) COMPOSITIONS AND METHODS FOR TREATING CANCER
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/100885    International Application No.:    PCT/US2004/014263
Publication Date: 25.11.2004 International Filing Date: 07.05.2004
IPC:
A61K 31/34 (2006.01)
Applicants: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA [US/US]; 3160 Chestnut Street, Suite 200, Philadelphia, PA 19104-6283 (US) (For All Designated States Except US).
THOMPSON, Craig, B. [US/US]; (US) (For US Only).
BAUER, Daniel [US/US]; (US) (For US Only).
HATZIVASSILIOU, Georgia [GR/US]; (US) (For US Only)
Inventors: THOMPSON, Craig, B.; (US).
BAUER, Daniel; (US).
HATZIVASSILIOU, Georgia; (US)
Agent: DELUCA, Mark; Cozen O'Connor, 1900 Market Street, Philadelphia, PA 19103 (US)
Priority Data:
60/469,233 09.05.2003 US
Title (EN) COMPOSITIONS AND METHODS FOR TREATING CANCER
(FR) COMPOSITIONS ET METHODES DE TRAITEMENT ANTICANCEREUX
Abstract: front page image
(EN)Methods of treating individuals identified as having cancer using ATP citrate lyase inhibitor and/or tricarboxylate transporter inhibitor are disclosed. Methods of inducing apoptosis in cancer cells using an ATP citrate lyase inhibitor and/or tricarboxylate transporter inhibitor are disclosed. Methods of treating an individual who has cancer comprising the steps of identifying the cancer as having a high rate of aerobic glycolysis, and administering an ATP citrate lyase inhibitor and/or tricarboxylate transporter inhibitor are disclosed. Methods of treating individuals who have cancer using compounds that inhibit the expression of ATP citrate lyase or tricarboxylate transporter are disclosed. Methods of identifying a compound with anticancer activity are disclosed.
(FR)L'invention concerne des méthodes consistant à traiter des individus chez lesquels un cancer a été diagnostiqué, par l'administration d'un inhibiteur de l'ATP-citrate lyase et/ou d'un inhibiteur du transporteur de tricarboxylate. L'invention porte également sur des méthodes permettant d'induire l'apoptose des cellules cancéreuses au moyen d'un inhibiteur de l'ATP-citrate lyase et/ou d'un inhibiteur du transporteur de tricarboxylate. L'invention se rapporte en outre à des méthodes permettant de traiter un individu atteint d'un cancer, les étapes de ces méthodes comprenant l'identification d'un cancer présentant un taux de glycolyse aérobie élevé, et l'administration d'un inhibiteur de l'ATP-citrate lyase et/ou d'un inhibiteur du transporteur de tricarboxylate. Enfin, l'invention concerne des méthodes consistant à traiter des individus atteints d'un cancer par l'administration de composés inhibant l'expression de l'ATP-citrate lyase ou du transporteur de tricarboxylate, ainsi que des méthodes permettant d'identifier un composé présentant une activité anticancéreuse.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)