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1. (WO2004099780) IMMUNOASSAYS FOR THE DETECTION OF UROKINASE RECEPTOR FORMS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/099780    International Application No.:    PCT/DK2004/000324
Publication Date: 18.11.2004 International Filing Date: 06.05.2004
IPC:
G01N 33/566 (2006.01), G01N 33/574 (2006.01)
Applicants: RIGSHOSPITALET [DK/DK]; Blegdamsvej 9, DK-2100 Copenhagen Ø (DK) (For All Designated States Except US).
PIIRONEN, Timo [FI/FI]; (FI) (For US Only).
HØYER-HANSEN, Gunilla [DK/DK]; (DK) (For US Only).
BRÜNNER, Nils [DK/DK]; (DK) (For US Only).
PLOUG, Michael [DK/DK]; (DK) (For US Only).
LIST, Karin [DK/US]; (US) (For US Only).
LAURSEN, Birgitte [DK/DK]; (DK) (For US Only).
DANØ, Keld [DK/DK]; (DK) (For US Only).
LILJAS, Hans [SE/SE]; (SE) (For US Only).
HAESE, Alexander [DE/DE]; (DE) (For US Only).
HARTWIG, Huland [DE/DE]; (DE) (For US Only).
TØRNBLOM, Magnus [SE/SE]; (SE) (For US Only).
GUSTAFSSON, Ove [SE/SE]; (SE) (For US Only)
Inventors: PIIRONEN, Timo; (FI).
HØYER-HANSEN, Gunilla; (DK).
BRÜNNER, Nils; (DK).
PLOUG, Michael; (DK).
LIST, Karin; (US).
LAURSEN, Birgitte; (DK).
DANØ, Keld; (DK).
LILJAS, Hans; (SE).
HAESE, Alexander; (DE).
HARTWIG, Huland; (DE).
TØRNBLOM, Magnus; (SE).
GUSTAFSSON, Ove; (SE)
Agent: PLOUGMANN & VINGTOFT A/S; P.O. Box 831, Sundkrogsgade 9, DK-2100 Copenhagen Ø (DK)
Priority Data:
PA 2003 00676 06.05.2003 DK
Title (EN) IMMUNOASSAYS FOR THE DETECTION OF UROKINASE RECEPTOR FORMS
(FR) DOSAGES IMMUNOLOGIQUES POUR LA DETECTION DE FORMES DE RECEPTEUR D'UROKINASE
Abstract: front page image
(EN)The present invention relates to the design of three novel monoclonal uPAR sandwich assays for the specific detection of 1) full-length intact uPAR, 2) full-length intact uPAR and domain 2+3 fragment, and 3) domain 1 fragment of uPAR. The invention further relates to a method combining the detected amounts of uPAR forms in a sample with data indicative of the presence of the cancer disease. The method can be used for staging, prognosis or diagnosis of prostate cancer. Two novel monoclonal antibodies and a kit and immunoassays for detecting at least one uPAR form(s) are also described in the present invention.
(FR)La présente invention a trait à la conception de trois nouveaux dosages de type sandwich du récepteur de l'activateur du plasminogène de type urokinase (uPAR) monoclonal pour la détection spécifique de 1) de l'uPAR intact pleine longueur, 2) de l'uPAR intact pleine longueur et de fragment 2+3 de domaine de liaison, et 3) de fragment 1 de domaine de liaison à l'uPAR. L'invention a également trait à un procédé combinant les quantités détectées de formes de l'uPAR dans un échantillon avec des données indiquant la présence de maladie cancéreuse. Le procédé peut être utilisé pour la stadification, le pronostic ou diagnostic de cancer de la prostate. L'invention a trait en outre à deux nouveaux anticorps monoclonaux et une trousse et des dosages immunologiques pour la détection d'au moins une forme de l'uPAR.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)