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1. (WO2004099402) GLYCOSYLATION VARIANTS OF BACE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/099402    International Application No.:    PCT/US2004/014387
Publication Date: 18.11.2004 International Filing Date: 30.04.2004
Chapter 2 Demand Filed:    25.02.2005    
IPC:
C12N 9/64 (2006.01)
Applicants: ELAN PHARMACEUTICALS, INC. [US/US]; 800 Gateway Boulevard, South San Francisco, CA 94080 (US) (For All Designated States Except US).
ANDERSON, John [US/US]; (US) (For US Only).
MCCONLOGUE, Lisa [US/US]; (US) (For US Only).
BASI, Guriqbal [US/US]; (US) (For US Only).
SINHA, Sukanto [US/US]; (US) (For US Only)
Inventors: ANDERSON, John; (US).
MCCONLOGUE, Lisa; (US).
BASI, Guriqbal; (US).
SINHA, Sukanto; (US)
Agent: GATTARI, Patrick, G.; McDonnell Boehnen Hulbert & Berghoff, 300 South Wacker Drive, Chicago, IL 60606 (US)
Priority Data:
60/467,509 02.05.2003 US
Title (EN) GLYCOSYLATION VARIANTS OF BACE
(FR) VARIANTS DE GLYCOSYLATION DE BACE
Abstract: front page image
(EN)Human BACE polypeptides having modifications to the N-linked glycosylation sites including one or more of the following amino acid substitutions: S1741, N233A, N153Q and N354S. DNA sequences, vectors, and host cells for producing the polypeptides. Crystalline protein compositions formed from the purified polypeptides. Methods of screening for compounds that inhibit A&bgr; using the polypeptides.
(FR)L'invention concerne des polypeptides de BACE humains présentant des modifications au niveau des sites de glycosylation à liaison N, notamment une ou plusieurs des substitutions d'acides aminés suivantes : S1741, N233A, N153Q et N354S. L'invention concerne des séquences d'ADN, des vecteurs et des cellules hôtes permettant de produire lesdits polypeptides. L'invention concerne des compositions protéiques cristallines constituées des polypeptides purifiés ainsi que des méthodes de criblage de composés qui inhibent l'A$g(b) à l'aide desdits polypeptides.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)