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1. (WO2004099243) TRUNCATED FORMS OF HUMAN DBF4, COMPLEXES WITH THEIR INTERACTING PARTNERS AND METHODS FOR IDENTIFICATION OF INHIBITORS THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/099243    International Application No.:    PCT/EP2004/050568
Publication Date: 18.11.2004 International Filing Date: 20.04.2004
Chapter 2 Demand Filed:    02.12.2004    
IPC:
C07K 14/47 (2006.01)
Applicants: PHARMACIA ITALIA S.P.A. [IT/IT]; Via Robert Koch, 1.2, I-20152 Milan (IT) (For All Designated States Except US).
VALSASINA, Barbara [IT/IT]; (IT).
CRISTIANI, Cinzia [IT/IT]; (IT) (For US Only).
KNAPP, Stefan [DE/IT]; (IT) (For US Only).
THIEFFINE, Sandrine [FR/IT]; (IT) (For US Only).
PEREGO, Rita [IT/IT]; (IT) (For US Only).
SACCARDO, Maria Beatrice [IT/IT]; (IT) (For US Only).
KALISZ, Henryk [GB/IT]; (IT) (For US Only)
Inventors: VALSASINA, Barbara; (IT).
CRISTIANI, Cinzia; (IT).
KNAPP, Stefan; (IT).
THIEFFINE, Sandrine; (IT).
PEREGO, Rita; (IT).
SACCARDO, Maria Beatrice; (IT).
KALISZ, Henryk; (IT)
Agent: MODIANO, Micaela, Nadia; Modiano Josif Pisanty & Staub Ltd., Baaderstrasse 3, 80469 München (DE)
Priority Data:
60/467,956 05.05.2003 US
Title (EN) TRUNCATED FORMS OF HUMAN DBF4, COMPLEXES WITH THEIR INTERACTING PARTNERS AND METHODS FOR IDENTIFICATION OF INHIBITORS THEREOF
(FR) FORMES TRONQUEES DE LA DBF4 HUMAINE, COMPLEXES AVEC LEURS PARTENAIRES D'INTERACTION ET PROCEDES DESTINES A L'IDENTIFICATION DE LEURS INHIBITEURS
Abstract: front page image
(EN)The present invention generally relates to the desing, expression and purification of truncated forms of the human dbf4 protein, optionally in complexe with dbf4 interacting partners, such as human cdc7, and its use in the discovery, indentification and characterization of inhibitors of the components of the complex, either when associated or when present as uncomplexed proteins in situ or in vitro. More specifically, the present invention relates to the utilization of specific truncated forms of human dbf4 for the production of an active, non-aggregated, monodispersed hetorodimer of human dbf4 complexed to human cdc7, or other protein interactors.
(FR)La présente invention concerne globalement la conception, l'expression et la purification de formes tronquées de la protéine dbf4 humaine, éventuellement dans un complexe avec des partenaires d'interaction de dbf4, telles que la cdc7 humaine, et son utilisation dans la découverte, l'identification et la caractérisation d'inhibiteurs des composants du complexe, soit lorsqu'ils sont associés, soit lorsqu'ils sont présents sous forme de protéines isolées in situ ou in vivo. La présente invention concerne plus précisément l'utilisation de formes tronquées spécifiques de la dbf4 humaine pour la production d'un hétérodimère monodispersé, non regroupé, actif, de la dbf4 humaine, combiné à une cdc7 humain, ou à tout autre élément d'interaction avec la protéine.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)