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1. (WO2004099208) PROCESS FOR THE PREPARATION OF FAMCICLOVIR
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/099208    International Application No.:    PCT/US2004/013427
Publication Date: 18.11.2004 International Filing Date: 30.04.2004
Chapter 2 Demand Filed:    28.02.2005    
IPC:
C07D 473/00 (2006.01)
Applicants: TEVA PHARMACEUTICAL INDUSTRIES LTD. [IL/IL]; Basel Street_5, P.O. Box 3190, 49131 Petah Tiqva (IL) (AE, AG, AL, AM, AT, AU, AZ, BA, BE, BF, BG, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NA, NE, NI, NL, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SI, SK, SL, SN, SY, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, YU, ZA, ZM, ZW only).
TEVA PHARMACEUTICALS USA, INC. [US/US]; 1090 Horsham Road, P.O. Box 1090, North Wales, PA 19454-1090 (US) (BB only).
SHAMAI, Genny [IL/IL]; (IL) (For US Only).
ANTEBI, Shlomo [IL/IL]; (IL) (For US Only).
IOFFE, David [IL/IL]; (IL) (For US Only).
DOLITZKY, Ben-Zion [IL/IL]; (IL) (For US Only).
KAUFFMANN, Batia [IL/IL]; (IL) (For US Only)
Inventors: SHAMAI, Genny; (IL).
ANTEBI, Shlomo; (IL).
IOFFE, David; (IL).
DOLITZKY, Ben-Zion; (IL).
KAUFFMANN, Batia; (IL)
Agent: BRAINARD, Charles, R.; Kenyon & Kenyon, One Broadway, New York, NY 10004-1050 (US)
Priority Data:
60/466,705 30.04.2003 US
60/488,268 16.07.2003 US
Title (EN) PROCESS FOR THE PREPARATION OF FAMCICLOVIR
(FR) PROCEDE DE PREPARATION DE FAMCICLOVIR
Abstract: front page image
(EN)The invention provides processes for making famciclovir with low levels of undesirable by-products. The present invention discloses a process comprises reacting a compound of formula I (acetic acid 2-acetoxymethyl-4-(5-amino-7-chloro-imidazo [4,5-b]pyridin-3-yl)-butyl ester) in the presence of a palladium on charcoal catalyst in a C1-C6 alkyl acetate and ammonium formate. The present invention further discloses a process comprises reacting a compound of formula I (acetic acid 2-­ acetoxymethyl-4-(5-amino-7-chloro-imidazo[4,5-b]pyridin-3-yl)-butyl ester) in the presence of a palladium on charcoal catalyst in a mixture of a C1-C6 alkyl acetate, a C1-C4 alcohol and ammonium formate.
(FR)L'invention concerne des procédés de fabrication de famciclovir avec des faibles doses de sous-produits indésirables. L'invention porte sur un procédé qui consiste à faire réagir un composé de formule I (ester de 2-acétoxyméthyl-4-(5-amino-7-chloro-imidazo [4,5-b]pyridin-3-yl)-butylique d'acide acétique) en présence d'un palladium sur un catalyseur au charbon dans un mélange d'acétate d'alkyle C1-C6 et de formate d'ammonium. L'invention porte également sur un procédé qui consiste à faire réagir un composé de formule I (ester de 2-acétoxyméthyl-4-(5-amino-7-chloro-imidazo [4,5-b]pyridin-3-yl)-butylique d'acide acétique) en présence d'un palladium sur un catalyseur au charbon dans un mélange d'acétate d'alkyle C1-C6, d'un alcool C1-C4 et d'un formate d'ammonium.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)