WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2004099185) 2-CYANOPYRROLIDINE DERIVATIVES AND THEIR USE AS DPP-IV INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/099185    International Application No.:    PCT/JP2004/006568
Publication Date: 18.11.2004 International Filing Date: 10.05.2004
IPC:
C07D 207/16 (2006.01), C07D 401/12 (2006.01), C07D 403/12 (2006.01), C07D 409/12 (2006.01), C07D 417/12 (2006.01)
Applicants: FUJISAWA PHARMACEUTICAL CO. LTD. [JP/JP]; 4-7, Doshomachi 3-chome, Chuo-ku, Osaka-shi, Osaka 5418514 (JP) (For All Designated States Except US).
SHIMA, Ichiro [JP/JP]; (JP) (For US Only).
KUROSAKI, Toshio [JP/JP]; (JP) (For US Only).
WADA, Aiko [JP/JP]; (JP) (For US Only)
Inventors: SHIMA, Ichiro; (JP).
KUROSAKI, Toshio; (JP).
WADA, Aiko; (JP)
Agent: UEKI, Kyuichi; Fujita-Toyobo Bldg. 9th Floor, 1-16, Dojima 2-chome, Kita-ku, Osaka-shi, Osaka 5300003 (JP)
Priority Data:
2003902260 09.05.2003 AU
Title (EN) 2-CYANOPYRROLIDINE DERIVATIVES AND THEIR USE AS DPP-IV INHIBITORS
(FR) DERIVES 2-CYANOPYRROLIDINE ET LEUR UTILISATION COMME INHIBITEURS DE LA DPP-IV
Abstract: front page image
(EN)A compound of the formula (I) or a pharmaceutically acceptable salt thereof: [wherein X is CFH, or CF?2#191, R¿1? is the moiety represented by the formula: [wherein R¿2? is (lower)alkyl, R¿3? is phenyl-(lower)alkyl, and the like.], and the like.] Compounds of formula (I) inhibit DPP-IV activity. They are therefore useful in the treatment of conditions mediated by DPP-IV, such as NIDDM.
(FR)Cette invention concerne un composé représenté par la formule (I) ou un sel pharmaceutiquement acceptable de ce composé. [Dans la formule (I), X désigne CFH ou CF2, R1 désigne la fraction représentée par la formule (II) [dans laquelle R2 désigne alkyl(inférieur), R3 désigne phényl-alkyl(inférieur) et analogue] et analogue]. Les composés représentés par la formule (I) inhibent l'activité de la DPP-IV. Ils sont par conséquent utilisés dans le traitement d'états induits par la DPP-IV, tels que le diabète non insulino-dépendant.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)