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1. (WO2004099155) 4-BROMO-5-(2-CHLORO-BENZOYLAMINO)-1H-PYRAZOLE-3-CARBOXYLIC ACID (PHENYL) AMIDE DERIVATES AND RELATED COMPOUNDS AS BRADYKININ B1 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMATORY DISEASES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/099155    International Application No.:    PCT/US2004/013655
Publication Date: 18.11.2004 International Filing Date: 30.04.2004
Chapter 2 Demand Filed:    02.12.2004    
IPC:
C07D 231/16 (2006.01), C07D 231/40 (2006.01), C07D 401/12 (2006.01), C07D 403/12 (2006.01), C07D 417/12 (2006.01)
Applicants: ELAN PHARMACEUTICALS, INC. [US/US]; 800 Gateway Boulevard, South San Francisco, CA 94080 (US) (For All Designated States Except US).
GAROFALO, Albert, W. [US/US]; (US) (For US Only).
TUNG, Jay, S. [US/US]; (US) (For US Only).
PLEISS, Michael, A. [US/US]; (US) (For US Only).
WU, Jing [US/US]; (US) (For US Only).
WONE, David, W., G. [US/US]; (US) (For US Only).
GUINN, Ashley, C. [US/US]; (US) (For US Only).
DRESSEN, Darren, B. [US/US]; (US) (For US Only).
MARUGG, Jennifer [US/US]; (US) (For US Only).
NEITZEL, Martin [US/US]; (US) (For US Only)
Inventors: GAROFALO, Albert, W.; (US).
TUNG, Jay, S.; (US).
PLEISS, Michael, A.; (US).
WU, Jing; (US).
WONE, David, W., G.; (US).
GUINN, Ashley, C.; (US).
DRESSEN, Darren, B.; (US).
MARUGG, Jennifer; (US).
NEITZEL, Martin; (US)
Agent: SWISS, Gerald, F.; Foley & Lardner LLP, 1530 Page Mill Road, Palo Alto, CA 94304-1125 (US)
Priority Data:
60/467,695 02.05.2003 US
60/503,652 17.09.2003 US
Title (EN) 4-BROMO-5-(2-CHLORO-BENZOYLAMINO)-1H-PYRAZOLE-3-CARBOXYLIC ACID (PHENYL) AMIDE DERIVATES AND RELATED COMPOUNDS AS BRADYKININ B1 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMATORY DISEASES
(FR) UTILISATION DE DERIVES DE PYRAZOLE SUBSTITUES SELECTIONNES ET DE COMPOSES ASSOCIES EN TANT QU'ANTAGONISTES DU RECEPTEUR B1 A LA BRADYKININE
Abstract: front page image
(EN)Disclosed are compounds that are bradykinin B1 receptor antagonists of formulae (I) and (II) and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykinin B1 receptor. Certain of the compounds exhibit increased potency and are also expected to exhibit increased duration of action. Formula (I) and (II) wherein Z’ is selected from O, S and NH; R1 is selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, cycloalkyl, substituted cycloalkyl, heteroaryl, substituted heteroaryl, heterocyclic and substituted heterocyclic; R2 is selected from the group consisting of hydrogen, alkyl, and substituted alkyl; R3 is selected from the group consisting of hydrogen, alkyl, and substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, cycloalkyl, substituted cycloalkyl, heteroaryl, substituted heteroaryl, heterocyclic and substituted heterocyclic; R4 is selected from the group consisting of aryl, substituted aryl, heteroaryl, and substituted heteroaryl; R5 is selected from the group consisting of hydrogen, alkyl and substituted alkyl; X is selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkoxy, substituted alkoxy, aryl, substituted aryl, carboxyl, carboxyl esters, cyano, halo, heteroaryl, substituted heteroaryl, hydroxy, nitro, amino, substituted amino, acylamino, and aminoacyl.
(FR)L'invention a trait à des composés, qui sont des antagonistes du récepteur B1 à la bradykinine et sont utiles pour traiter des maladies ou soulager des symptômes indésirables associés à des états pathologiques chez des mammifères, lesdits maladies et états pathologiques étant induits par le récepteur B1 à la bradykinine. Certains desdits composés présentent une puissance améliorée, et sont considérés comme ayant en outre une action de plus longue durée.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)