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1. (WO2004099150) 3-(1-NAPHTHYL)-2-CYANOPROPANOIC ACID DERIVATIVES AS ESTROGEN RECEPTOR LIGANDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/099150    International Application No.:    PCT/US2004/013360
Publication Date: 18.11.2004 International Filing Date: 30.04.2004
IPC:
A61K 31/277 (2006.01), A61K 31/44 (2006.01), A61K 31/47 (2006.01), A61K 31/495 (2006.01), A61K 31/496 (2006.01), A61P 29/00 (2006.01), C07C 255/19 (2006.01), C07D 205/04 (2006.01), C07D 209/08 (2006.01), C07D 211/18 (2006.01), C07D 211/82 (2006.01), C07D 213/74 (2006.01), C07D 215/00 (2006.01), C07D 215/14 (2006.01), C07D 217/06 (2006.01), C07D 217/16 (2006.01), C07D 295/185 (2006.01)
Applicants: WYETH [US/US]; Five Giralda Farms, Madison, NJ 07940 (US) (For All Designated States Except US).
CAGGIANO, Thomas, J. [US/US]; (US) (For US Only).
BRAZZALE, Antony, A. [US/US]; (US) (For US Only).
MOORE, William, Jay [US/US]; (US) (For US Only).
KIM, Callain, Younghee [US/US]; (US) (For US Only)
Inventors: CAGGIANO, Thomas, J.; (US).
BRAZZALE, Antony, A.; (US).
MOORE, William, Jay; (US).
KIM, Callain, Younghee; (US)
Agent: LUCCI, Joseph; Woodcock Washburn LLP, One Liberty Place, 46th Floor, Philadelphia, PA 19103 (US)
Priority Data:
60/466,567 30.04.2003 US
10/833,678 28.04.2004 US
Title (EN) 3-(1-NAPHTHYL)-2-CYANOPROPANOIC ACID DERIVATIVES AS ESTROGEN RECEPTOR LIGANDS
(FR) DERIVES D'AMIDES ET D'ESTERS D'ACIDE 2-CYANOPROPANOIQUE ET METHODES D'UTILISATION DESDITS DERIVES
Abstract: front page image
(EN)This invention provides compounds of formula (I) or a pharmaceutically acceptable salt thereof that are useful for the treatment of the inflammatory component of diseases and are particularly useful in treating atherosclerosis, myocardial infarction, congestive heart failure, inflammatory bowel disease, arthritis, type II diabetes, and autoimmune diseases such as multiple sclerosis and rheumatiod arthritis.
(FR)L'invention concerne des composés représentés par la formule (I), ou un sel pharmaceutiquement acceptable de ceux-ci. Ces composés sont utiles dans le traitement de la composante inflammatoire de maladies et sont particulièrement utiles dans le traitement de l'athérosclérose, de l'infarctus du myocarde, de l'insuffisance cardiaque globale, de la maladie intestinale inflammatoire, de l'arthrite, du diabète du type II et des maladies auto-immunes, telles que la sclérose en plaques et la polyarthrite rhumatoïde.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)