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Machine translation
1. (WO2004099146) BENZAMIDE INHIBITORS OF THE P2X7 RECEPTOR
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2004/099146 International Application No.: PCT/IB2004/001525
Publication Date: 18.11.2004 International Filing Date: 10.05.2004
Chapter 2 Demand Filed: 19.07.2004
IPC:
C07D 213/56 (2006.01) ,C07D 231/12 (2006.01) ,C07D 233/54 (2006.01) ,C07D 237/14 (2006.01) ,C07D 249/04 (2006.01) ,C07D 261/08 (2006.01) ,C07D 277/30 (2006.01) ,C07D 403/12 (2006.01) ,C07D 405/06 (2006.01)
Applicants: DOMBROSKI, Mark, Anthony[US/US]; US (UsOnly)
DUPLANTIER, Allen, Jacob[US/US]; US (UsOnly)
SUBRAMANYAM, Chakrapani[IN/US]; US (UsOnly)
PFIZER PRODUCTS INC.[US/US]; Eastern Point Road Groton, CT 06340, US (AllExceptUS)
Inventors: DOMBROSKI, Mark, Anthony; US
DUPLANTIER, Allen, Jacob; US
SUBRAMANYAM, Chakrapani; US
Agent: FULLER, Grover, F., Jr.; Pfizer Inc. 201 Tabor Road Morris Plains, NJ 07950, US
Priority Data:
60/470,00112.05.2003US
Title (EN) BENZAMIDE INHIBITORS OF THE P2X7 RECEPTOR
(FR) INHIBITEURS BENZAMIDIQUES DU RECEPTEUR P2X7
Abstract: front page image
(EN) The present invention provides benzamide inhibitors of the P2X7 receptor of the formula (I), wherein R1 -R3 are as defined herein. The compounds of the invention are useful in the treatment of IL-1 mediated disorders, including, without limitation, inflammatory diseases such as osteoarthritis and rheumatoid arthritis; allergies, asthma, COPD, cancer, reperfusion or ischemia in stroke or heart attack, autoimmune diseases and other disorders.
(FR) La présente invention se rapporte à des inhibiteurs benzamidiques du récepteur P2X7 répondant à la formule (I), dans laquelle R1 à R3 ont les définitions données dans la description. Les composés selon l'invention sont utilisables dans le traitement des troubles à médiation par IL-1, à savoir notamment mais non exclusivement les maladies inflammatoires telles que l'arthrose et l'arthrite rhumatoïde ; les allergies, l'asthme, la bronchopneumopathie chronique obstructive, les cancers, la reperfusion ou l'ischémie en cas d'accident vasculaire cérébral ou d'infarctus, les maladies auto-immunes et d'autres troubles.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)