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Machine translation
1. (WO2004098644) PRODRUGS CLEAVABLE BY CD26
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/098644    International Application No.:    PCT/BE2004/000069
Publication Date: 18.11.2004 International Filing Date: 10.05.2004
Chapter 2 Demand Filed:    25.11.2004    
IPC:
A61K 38/00 (2006.01), A61K 47/48 (2006.01), C07D 493/04 (2006.01), C07H 15/252 (2006.01), C07K 5/06 (2006.01), C07K 5/062 (2006.01), C07K 5/065 (2006.01), C07K 5/068 (2006.01), C07K 5/072 (2006.01), C07K 5/083 (2006.01), C07K 5/103 (2006.01), C07K 5/11 (2006.01), C07K 5/113 (2006.01), C07K 7/06 (2006.01), C07K 9/00 (2006.01)
Applicants: K.U. LEUVEN RESEARCH & DEVELOPMENT [BE/BE]; Groot-Begijnhof, Benedenstraat 58, B-3000 Leuven (BE) (For All Designated States Except US).
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC) [ES/ES]; C/Serrano 117, 28006 Madrid (ES) (For All Designated States Except US).
BALZARINI, Jan [BE/BE]; (BE) (For US Only).
CAMARASA RIUS, Maria José [ES/ES]; (ES) (For US Only).
SONSOLES VELAZQUES DIAZ [ES/ES]; (ES) (For US Only)
Inventors: BALZARINI, Jan; (BE).
CAMARASA RIUS, Maria José; (ES).
SONSOLES VELAZQUES DIAZ; (ES)
Agent: BIRD, William; Bird Goën & Co., Klein Dalenstraat 42 A, B-3020 Winksele (BE)
Priority Data:
0310593.9 08.05.2003 GB
Title (EN) PRODRUGS CLEAVABLE BY CD26
(FR) PROMEDICAMENTS POUVANT ETRE CLIVES A MOYEN DE CD26
Abstract: front page image
(EN)The present invention provides a new prodrug technology and new prodrugs in order to increase the solubility, to modulate plasma protein binding or to enhance the biovailability of a drug. In the present invention the prodrugs are conjugates of a therapeutic compound and a peptide (eg tetrapeptide or hexapeptide) wherein the conjugate is cleavable by dipeptidyl-peptidases, more preferably by CD26, also known as DPPIV (dipeptidyl aminodipeptidase IV). The present invention furthermore provides a method of producing said prodrugs, to enhance brain and lymphatic delivery of drugs and/or to extend drug half-lives in plasma.
(FR)L'invention concerne une technologie de promédicaments et des promédicaments permettant d'accroître la solubilité, aux fins de modulation de la liaison aux protéines plasmatiques ou d'amélioration de la biodisponibilité d'un médicament. Selon l'invention, les promédicaments sont des conjugués d'un composé thérapeutique et d'un peptide (par exemple, un tétrapeptide ou un hexapeptide), le conjugué pouvant être clivé par des dipeptidyl-peptidases, de préférence par CD26, aussi connu sous DPPIV (dipeptidyl aminodipeptidase IV). L'invention concerne également un procédé de production des promédicaments et une technologie des promédicaments permettant de cibler ceux-ci de manière plus sélective, aux fins d'amélioration de l'administration cérébrale et lymphatique de médicaments et/ou de prolongation des demi-vies des médicaments dans le plasma.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)