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1. (WO2004098509) COMPOSITIONS FOR INDUCING IMMUNE RESPONSES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2004/098509 International Application No.: PCT/US2004/013407
Publication Date: 18.11.2004 International Filing Date: 30.04.2004
IPC:
A61K 39/21 (2006.01) ,A61K 45/00 (2006.01) ,C12Q 1/70 (2006.01)
Applicants: O'HAGAN, Derek[US/US]; US (UsOnly)
SINGH, Manmohan[IN/US]; US (UsOnly)
CHIRON CORPORATION[US/US]; 4560 Horton Street M/S R338 Emeryville, CA 94608-2916, US (AllExceptUS)
Inventors: O'HAGAN, Derek; US
SINGH, Manmohan; US
Agent: ALEXANDER, Lisa, E.; Corporate Patent Counsel 4560 Horton Street M/S R338 Emeryville, CA 94608-2916, US
Priority Data:
60/466,94830.04.2003US
Title (EN) COMPOSITIONS FOR INDUCING IMMUNE RESPONSES
(FR) COMPOSITIONS INDUISANT DES REPONSES IMMUNITAIRES
Abstract:
(EN) The invention provides, inter alia, immunogenic compositions comprising a first antigen, at least two adjuvants, wherein a first adjuvant comprises a polymer derived from poly(lactides) and/or poly(lactide-co-glycolides), and wherein a second adjuvant comprises an imidazoquinoline, wherein said first antigen is encapsulated within, adsorbed or conjugated to, co-lyophilized or mixed with said first adjuvant, and a pharmaceutically acceptable excipient, wherein said composition elicits a cellular immune response when administered to a vertebrate subject. The invention also provides methods of producing immunogenic compositions, methods for producing a cytotoxic-T lymphocyte (CTL) response in a vertebrate subject, and methods of immunization.
(FR) L'invention concerne, entre autres, des compositions immunogènes comprenant un premier antigène, au moins deux adjuvants, le premier adjuvant contenant un polymère dérivé de poly(lactides) et/ou de poly(lactide-co-glycolides), et le second adjuvant comprenant un imidazoquinoline, ledit premier antigène étant encapsulé dans, adsorbé ou conjugué à, co-lyophilisé ou mélangé audit premier adjuvant, ainsi qu'un excipient pharmaceutiquement acceptable. Cette composition élicitant une réponse immunitaire cellulaire lorsqu'elle est administrée à un vertébré. Par ailleurs, l'invention concerne des procédés de production de compositions immunogènes, des procédés de production d'une réponse immunitaire induite par les cellules T tueuses (CTL) chez un vertébré, et enfin, des procédés d'immunisation.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)