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1. (WO2004098495) MEDICAL DEVICES AND METHODS FOR INHIBITING PROLIFERATION OF SMOOTH MUSCLE CELLS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/098495    International Application No.:    PCT/US2004/011757
Publication Date: 18.11.2004 International Filing Date: 16.04.2004
IPC:
A61K 31/00 (2006.01), A61K 31/165 (2006.01), A61K 31/19 (2006.01), A61K 38/15 (2006.01), A61L 29/16 (2006.01), A61L 31/16 (2006.01)
Applicants: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK [US/US]; 412 Low Library, Mail Code 4308, 535 West 116th Street, New York, NY 10027 (US)
Inventors: MARX, Steven, O.; (US).
MARKS, Andrew, Robert; (US)
Agent: RESTAINO, Leslie, Gladstone; Thelen Reid & Priest, 200 Campus Drive, Suite 210, Florham Park, NJ 07932 (US)
Priority Data:
10/425,354 28.04.2003 US
Title (EN) MEDICAL DEVICES AND METHODS FOR INHIBITING PROLIFERATION OF SMOOTH MUSCLE CELLS
(FR) DISPOSITIFS ET PROCEDE MEDICAUX SERVANT A INHIBER LA PROLIFERATION DE CELLULES DES MUSCLES LISSES
Abstract: front page image
(EN)The present invention provides HDAC inhibitors for use in inhibiting proliferation and/or migration of smooth muscle cells. The present invention further provides medical devices coated with the HDAC inhibitors. The present invention also provides use of the medical devices in methods for inhibiting proliferation and/or migration of smooth muscle cells. Additionally, the present invention provides methods for inhibiting proliferation and/or migration of non-neoplastic smooth muscle cells. Finally, the present invention provides methods for preventing or treating restenosis after angioplasty or stent implantation in a subject.
(FR)L'invention concerne des inhibiteurs de HDAC servant à inhiber la prolifération et/ou la migration de cellules des muscles lisses. Elle concerne également des dispositifs médicaux revêtus par ces inhibiteurs de HDAC. Elle concerne également l'utilisation de ces dispositifs médicaux dans des procédés servant à inhiber la prolifération et/ou la migration de cellules des muscles lisses. Elle concerne, de plus, des procédés servant à inhiber la prolifération et/ou la migration de cellules des muscles lisses non néoplasiques. Elle concerne enfin des procédés servant à prévenir ou à traiter la resténose après l'angioplastie ou l'implantation d'un extenseur chez un patient.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)