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1. (WO2004097034) DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH HUMAN TRANSMEMBRANE SERINE PROTEASE 4 (TMPRSS4)
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/097034    International Application No.:    PCT/EP2004/004164
Publication Date: 11.11.2004 International Filing Date: 20.04.2004
IPC:
C12Q 1/37 (2006.01), G01N 33/574 (2006.01), G01N 33/68 (2006.01)
Applicants: BAYER HEALTHCARE AG [DE/DE]; 51368 Leverkusen (DE) (For All Designated States Except US).
GOLZ, Stefan [DE/DE]; (DE) (For US Only).
BRÜGGEMEIER, Ulf [DE/DE]; (DE) (For US Only).
GEERTS, Andreas [DE/DE]; (DE) (For US Only).
POLEJ, Stefanie [DE/DE]; (DE) (For US Only)
Inventors: GOLZ, Stefan; (DE).
BRÜGGEMEIER, Ulf; (DE).
GEERTS, Andreas; (DE).
POLEJ, Stefanie; (DE)
Common
Representative:
BAYER HEALTHCARE AG; 51368 Leverkusen (DE)
Priority Data:
03010004.4 02.05.2003 EP
Title (EN) DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH HUMAN TRANSMEMBRANE SERINE PROTEASE 4 (TMPRSS4)
(FR) AGENTS DIAGNOSTIQUES ET THERAPEUTIQUES DESTINES A DES MALADIES ASSOCIEES A LA SERINE PROTEASE 4 TRANSMEMBRANAIRE HUMAINE (TMPRSS4)
Abstract: front page image
(EN)The invention provides a human TMPRSS4 which is associated with the cardiovascular disorders, endocrinological diseases, gastroenterological diseases, urological disorders, metabolic dieases, cancer, respiratory diseases and dermatological diseaes. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, endocrinological diseases, gastroenterological diseases, urological disorders, metabolic dieases, cancer, respiratory diseases and dermatological diseaes. The invention also features compounds which bind to and/or activate or inhibit the activity of TMPRSS4 as well as pharmaceutical compositions comprising such compounds.
(FR)L'invention concerne une sérine protéase humaine TMPRSS4 associée à des troubles cardiovasculaires, des maladies endocrines, des maladies gastroentérologiques, des maladies urologiques, des maladies métaboliques, le cancer, des maladies respiratoires, et des maladies dermatologiques. L'invention concerne également des dosages destinés à l'identification de composés servant au traitement ou à la prévention de troubles cardiovasculaires, de maladies endocrines, de maladies gastroentérologiques, de maladies urologiques, de maladies métaboliques, du cancer, de maladies respiratoires, de maladies urologiques et de maladies dermatologiques. L'invention concerne par ailleurs des composés se liant à la sérine protéase humaine TMPRSS4 et/ou activant ou inhibant l'activité de la sérine protéase humaine TMPRSS4, ainsi que des compositions pharmaceutiques contenant de tels composés.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)