WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |

Search International and National Patent Collections
World Intellectual Property Organization
Machine translation
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/096832    International Application No.:    PCT/US2004/013170
Publication Date: 11.11.2004 International Filing Date: 29.04.2004
A61K 38/00 (2006.01), C07K 14/00 (2006.01), C12N 15/74 (2006.01), C12Q 1/70 (2006.01)
Applicants: CHILDREN'S MEDICAL CENTER CORPORATION [US/US]; 55 Shattuck Street, Boston, MA 02115 (US) (For All Designated States Except US).
MOSES, Marsha, A. [US/US]; (US) (For US Only).
FERNANDEZ, Cecilia, A. [US/US]; (US) (For US Only)
Inventors: MOSES, Marsha, A.; (US).
FERNANDEZ, Cecilia, A.; (US)
Agent: RESNICK, David, S.; Nixon Peabody LLP, 100 Summer Street, Boston, MA 02110 (US)
Priority Data:
60/466,502 29.04.2003 US
Abstract: front page image
(EN)The present invention provides an antiangiogenic polypeptide having the amino acid sequence set forth in SEQ ID No: 1, or a fragment thereof, which is effective to inhibit endothelial cell proliferation as determined by the capillary EC proliferation assay. Preferably, the fragment has at least 50% inhibition of bFGF-stimulated EC proliferation at 5 µg/ml-20 µg/ml, more preferably 75% inhibition, most preferably 95% inhibition.
(FR)L'invention concerne un polypeptide anti-angiogénique possédant une séquence d'acides aminés définie dans SEQ ID No: 1, ou un fragment de celle-ci, efficace en vue d'inhiber la prolifération de cellules endothéliales, comme déterminé par le test de prolifération capillaire EC. De préférence, le fragment présente au moins 50% d'inhibition de prolifération EC simulée bFGF à 5 $g(m)g/ml-20 $g(m)g/ml, mieux encore 75% d'inhibition et idéalement 95 % d'inhibition.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)