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1. (WO2004096257) GENETIC MODIFICATION OF TARGETED REGIONS OF THE CARDIAC CONDUCTION SYSTEM
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/096257    International Application No.:    PCT/US2004/011094
Publication Date: 11.11.2004 International Filing Date: 09.04.2004
IPC:
A61K 38/17 (2006.01)
Applicants: MEDTRONIC, INC. [US/US]; MS LC340, 710 Medtronic Parkway, Minneapolis, MN 55432 (US) (For All Designated States Except US).
OLSON, Walter, H. [US/US]; (US) (For US Only).
SHARMA, Vinrod [US/US]; (US) (For US Only)
Inventors: OLSON, Walter, H.; (US).
SHARMA, Vinrod; (US)
Agent: WOLDE-MICHAEL, Girma; MS LC340, 710 Medtronic Parkway, Minneapolis, MN 55432 (US)
Priority Data:
10/423,595 25.04.2003 US
Title (EN) GENETIC MODIFICATION OF TARGETED REGIONS OF THE CARDIAC CONDUCTION SYSTEM
(FR) MODIFICATION GENETIQUE DE REGIONS CIBLEES DU SYSTEME DE CONDUCTION CARDIAQUE
Abstract: front page image
(EN)Disclosed are methods and systems for preventing or treating cardiac dysfunction, particularly cardiac pacing dysfunction by genetic modification of the conduction system of the heart. In one embodiment, the invention provides a method of genetically modifying the cells by delivering to the cells one or more coding sequence in a genetic construct capable of modifying the expression of ion channels of the cells.
(FR)L'invention concerne des procédés et des systèmes de prévention ou de traitement d'un dysfunctionnement cardiaque, en particulier un dysfunctionnement de stimulation cardiaque, par modification génétique du système de conduction cardiaque. Dans un mode de réalisation, on décrit un procédé de modification génétique des cellules, qui consiste à transmettre aux cellules une ou plusieurs séquences de codage dans une construction génétique pouvant modifier l'expression des canaux ioniques des cellules.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)