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1. (WO2004096229) MEDICINAL COMPOSITION IN SOLUTION FORM
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/096229    International Application No.:    PCT/JP2004/006159
Publication Date: 11.11.2004 International Filing Date: 28.04.2004
Chapter 2 Demand Filed:    23.02.2005    
IPC:
A61K 31/5375 (2006.01)
Applicants: Dainippon Sumitomo Pharma Co., Ltd. [JP/JP]; 6-8, Dosho-machi 2-chome, Chuo-ku, Osaka-shi, Osaka 5418524 (JP) (For All Designated States Except US).
HIGAKI, Masaru [JP/JP]; (JP) (For US Only).
MURAKAMI, Takayuki [JP/JP]; (JP) (For US Only)
Inventors: HIGAKI, Masaru; (JP).
MURAKAMI, Takayuki; (JP)
Agent: KAWAMIYA, Osamu; AOYAMA & PARTNERS IMP Building 3-7, Shiromi 1-chome Chuo-ku, Osaka-shi Osaka 5400001 (JP)
Priority Data:
2003-124694 30.04.2003 JP
Title (EN) MEDICINAL COMPOSITION IN SOLUTION FORM
(FR) COMPOSITION MEDICAMENTEUSE EN SOLUTION
(JA) 溶液医薬組成物
Abstract: front page image
(EN)A medicinal composition in a solution form which comprises (a) 4-amino-5-chloro-2-ethoxy-N-[[4-(4-fluorobenzyl)-2- morpholinyl]methyl]benzamide (compound (A)) or a physiologically acceptable salt thereof, (b) propylene glycol, and (c) water. The solution-form medicinal composition containing the compound (A) is useful as an injection or peroral drug. That is, the solution-form medicinal composition has a solubility and pH both in desired ranges and is highly stable.
(FR)La présente invention a trait à une composition médicamenteuse en solution comprenant (a) un composé 4-amino-5-chloro-2-éthoxy-N-[4-(4-fluorobenzyl)-2-morpholinyl]méthyl]benzamide (composé A) ou un de ses sels pharmaceutiquement acceptables, (b) du propylène glycol, et (c) de l'eau. La composition médicamenteuse en solution contenant le composé (A) est utile sous forme d'injection ou de médicament peroral. En d'autres mots, la composition médicamenteuse en solution présente une solubilité et un pH dans des plages souhaitées et présente une grande stabilité.
(JA) 本発明は、(a)4−アミノ−5−クロロ−2−エトキシ−N−[[4−(4−フルオロベンジル)−2−モルホリニル]メチル]ベンズアミド(化合物A)又はその生理学的に許容される塩、(b)プロピレングリコール及び(c)水を含有する溶液医薬組成物に関する。本発明によれば、注射剤や経口剤として有用な化合物A含有溶液医薬組成物、即ち、溶解度とpHが共に望まれる範囲内にあり、且つ安定性の高い溶液医薬組成物を提供することができる。
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)