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1. (WO2004096224) COMBINATIONS FOR THE TREATMENT OF DISEASES INVOLVING CELL PROLIFERATION, MIGRATION OR APOPTOSIS OF MYELOMA CELLS, OR ANGIOGENESIS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/096224    International Application No.:    PCT/EP2004/004363
Publication Date: 11.11.2004 International Filing Date: 24.04.2004
IPC:
A61K 31/496 (2006.01), A61K 31/517 (2006.01), A61K 31/56 (2006.01), A61K 45/06 (2006.01)
Applicants: BOEHRINGER INGELHEIM INTERNATIONAL GMBH [DE/DE]; Binger Strasse 173, 55216 Ingelheim (DE) (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CY, CZ, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, SZ, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, YU, ZA, ZM, ZW only).
BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG [DE/DE]; Binger Strasse 173, 55216 Ingelheim (DE) (DE only).
HILBERG, Frank [DE/AT]; (AT) (For US Only).
SOLCA, Flavio [CH/AT]; (AT) (For US Only).
STEFANIC, Martin Friedrich [DE/DE]; (DE) (For US Only).
BAUM, Anke [DE/AT]; (AT) (For US Only).
MUNZERT, Gerd [DE/DE]; (DE) (For US Only).
VAN MEEL, Jacobus, C.A. [NL/AT]; (AT) (For US Only)
Inventors: HILBERG, Frank; (AT).
SOLCA, Flavio; (AT).
STEFANIC, Martin Friedrich; (DE).
BAUM, Anke; (AT).
MUNZERT, Gerd; (DE).
VAN MEEL, Jacobus, C.A.; (AT)
Agent: Boehringer Ingelheim International GMBH; Binger Strasse 173, 55216 Ingelheim (DE)
Priority Data:
03009587.1 29.04.2003 EP
04000508.4 13.01.2004 EP
04001171.0 21.01.2004 EP
Title (EN) COMBINATIONS FOR THE TREATMENT OF DISEASES INVOLVING CELL PROLIFERATION, MIGRATION OR APOPTOSIS OF MYELOMA CELLS, OR ANGIOGENESIS
(FR) COMBINAISONS POUR TRAITER DES MALADIES IMPLIQUANT LA PROLIFERATION CELLULAIRE, LA MIGRATION OU L'APOPTOSE DE CELLULES DU MYELOME OU L'ANGIOGENESE
Abstract: front page image
(EN)The present invention relates to a pharmaceutical combination for the treatment of diseases which involves cell proliferation, migration or apoptosis of myeloma cells, or angiogenesis. The invention also relates to a method for the treatment of said deseases, coomprising co-administration of effective amounts of specific active compounds and/or co-treatment with radiation therapy, in a ratio which provides an additive and synergistic effect, and to the combined use of these specific compounds and/or radiotherapy for the manufacture of corresponding pharmaceutical combination preparations.
(FR)L'invention concerne une combinaison pharmaceutique pour le traitement de maladies qui impliquent la prolifération cellulaire, la migration ou l'apoptose de cellules de myélome ou l'angiogénèse. L'invention concerne également un procédé pour traiter lesdites maladies, comprenant la co-administration de quantités efficaces de composés actifs sélectifs et/ou un co-traitement par radiothérapie, à un taux qui produit un effet additif et synergique. L'invention concerne en outre, l'utilisation combinée des composés spécifiques et/ou de la radiothérapie pour fabriquer les préparations de combinaisons pharmaceutiques correspondantes.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)