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1. (WO2004094659) ASSOCIATIONS OF POLYMORPHISMS IN THE FRZB GENE WITH OBESITY AND OSTEOPOROSIS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/094659    International Application No.:    PCT/EP2004/004178
Publication Date: 04.11.2004 International Filing Date: 20.04.2004
IPC:
C12Q 1/68 (2006.01)
Applicants: ROCHE DIAGNOSTICS GMBH [DE/DE]; Sandhofer Strasse 116, 68305 Mannheim (DE) (DE only).
F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124, CH-4070 Basel (CH) (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DK, DM, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NA, NE, NI, NL, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SI, SK, SL, SN, SY, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW only).
HIGUCHI, Russell, Gene [US/US]; (US) (For US Only).
PELTZ, Gary, Allen [US/US]; (US) (For US Only).
FIJAL, Bonnie [US/US]; (US) (For US Only).
RO, Sunhee, Kwon [KR/US]; (US) (For US Only).
LI, Jia [US/US]; (US) (For US Only)
Inventors: HIGUCHI, Russell, Gene; (US).
PELTZ, Gary, Allen; (US).
FIJAL, Bonnie; (US).
RO, Sunhee, Kwon; (US).
LI, Jia; (US)
Common
Representative:
ROCHE DIAGNOSTICS GMBH; Patent Department, 68298 Mannheim (DE)
Priority Data:
60/464,372 21.04.2003 US
60/526,689 02.12.2003 US
Title (EN) ASSOCIATIONS OF POLYMORPHISMS IN THE FRZB GENE WITH OBESITY AND OSTEOPOROSIS
(FR) LIENS ENTRE DES POLYMORPHISMES DANS LE GENE FRZB ET L'OBESITE ET L'OSTEOPOROSE
Abstract: front page image
(EN)Methods and reagents for determining sequence variants present at the FRZB locus, which facilitate identifying individuals at risk for obesity and/or osteoporosis, are provided. In particular, methods for detecting an individual's risk for obesity and/or osteoporosis by detecting at least one polymorphism (e.g., at least one single nucleotide polymorphism) in the FRZB gene in a nucleic acid sample from the individual are provided. Related kits, arrays and systems are also described.
(FR)L'invention concerne des méthodes et des réactifs permettant de détecter des variants de séquences présents au niveau du locus FRZB, facilitant l'identification d'individus présentant un risque d'obésité et/ou d'ostéoporose. Ces méthodes permettent plus particulièrement de détecter le risque d'un individu de développer une obésité et/ou une ostéoporose. Ces méthodes consistent à détecter au moins un polymorphisme (au moins un polymorphisme simple nucléotide, par exemple) dans le gène FRZB, dans un échantillon d'acide nucléique prélevé sur l'individu. L'invention concerne également des kits, des réseaux et des systèmes associés.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)