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Machine translation
1. (WO2004094405) 4-, 6- O 7-HYDROXYINDOLES HAVING N-OXIDE GROUPS AND THE USE THEREOF AS THERAPEUTIC AGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/094405    International Application No.:    PCT/EP2004/004338
Publication Date: 04.11.2004 International Filing Date: 23.04.2004
Chapter 2 Demand Filed:    15.10.2004    
IPC:
C07D 401/12 (2006.01)
Applicants: ELBION AG [DE/DE]; Meissner Strasse 191, 01445 Radebeul (DE) (For All Designated States Except US).
HÖFGEN, Norbert [DE/DE]; (DE) (For US Only).
KUSS, Hildegard [DE/DE]; (DE) (For US Only).
STEINIKE, Karin [DE/DE]; (DE) (For US Only).
EGERLAND, Ute [DE/DE]; (DE) (For US Only).
RUNDFELDT, Chris [DE/DE]; (DE) (For US Only)
Inventors: HÖFGEN, Norbert; (DE).
KUSS, Hildegard; (DE).
STEINIKE, Karin; (DE).
EGERLAND, Ute; (DE).
RUNDFELDT, Chris; (DE)
Agent: WEICKMANN & WEICKMANN; Postfach 860 820, 81635 München (DE)
Priority Data:
103 18 611.5 24.04.2003 DE
Title (DE) 4-, 6- ODER 7-HYDROXYINDOLE MIT N-OXIDGRUPPEN UND DEREN VERWENDUNG ALS THERAPEUTIKA
(EN) 4-, 6- O 7-HYDROXYINDOLES HAVING N-OXIDE GROUPS AND THE USE THEREOF AS THERAPEUTIC AGENTS
(FR) 4-, 6- OU 7-HYDROXYINDOLES A GROUPES N-OXYDE ET LEUR UTILISATION COMME PRODUITS THERAPEUTIQUES
Abstract: front page image
(DE)Die Erfindung betrifft substituierte 4-, 6- oder 7-Hydroxyindole mit N-Oxidgruppen der Formel (I), Verfahren zu deren Herstellung, pharmazeutische Zubereitungen, die diese Verbindungen enthalten sowie die pharmazeutische Verwendung dieser Verbindungen, die Inhibitoren der Phosphodiesterase 4 sind, als Wirkstoffe zur Behandlung von Erkrankungen, die mit einer Hemmung der Phosphodiesterase 4-Aktivität insbesondere in immunkompetenten Zellen (z.B. Makrophagen und Lymphozyten) durch die erfindungsgemässen Verbindungen zu beeinflussen sind.
(EN)The invention relates to substituted 4-, 6- or 7-hydroxyindoles having N-oxide groups of formula (I), a method for the production thereof, pharmaceutical preparations comprising said compounds and the pharmaceutical use of said compounds which are inhibitors of phosphodiesterase 4, as active substances in the treatment of diseases which can be influenced by said inventive compounds by means of an inhibition of phosphodiesterase 4 activity, especially in immunocompetent cells (for example, macrophages and lymphocytes).
(FR)L'invention concerne des 4-, 6- ou 7-hydroxyindoles substitués à groupes N-oxyde de formule (I), des procédés de production de ces composés, des préparations pharmaceutiques contenant ces composés ainsi que l'utilisation pharmaceutique de ces composés, inhibiteurs de la phosphodiestérase 4, comme principes actifs dans le traitement de maladies nécessitant une inhibition de l'activité de la phosphodiestérase 4 en particulier dans des cellules immunocompétentes (p. ex. macrophages et lymphocytes) par les composés de la présente invention.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: German (DE)
Filing Language: German (DE)