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1. (WO2004093783) MODULATION OF APOLIPOPROTEIN C-III EXPRESSION
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2004/093783 International Application No.: PCT/US2004/010946
Publication Date: 04.11.2004 International Filing Date: 15.04.2004
IPC:
A61K 38/00 (2006.01) ,C07H 21/04 (2006.01) ,C12N 15/11 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
04
with deoxyribosyl as saccharide radical
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
Applicants:
ISIS PHARMACEUTICALS, INC. [US/US]; 2292 Faraday Avenue Carlsbad, CA 92008, US (AllExceptUS)
CROOKE, Rosanne, M. [US/US]; US (UsOnly)
GRAHAM, Mark, J. [US/US]; US (UsOnly)
LEMONIDIS TARBET, Kristina, M. [US/US]; US (UsOnly)
DOBIE, Kenneth, W. [GB/US]; US (UsOnly)
Inventors:
CROOKE, Rosanne, M.; US
GRAHAM, Mark, J.; US
LEMONIDIS TARBET, Kristina, M.; US
DOBIE, Kenneth, W.; US
Agent:
BAK, Mary, E.; Howson and Howson 321 Norristown Road, Suite 200 Spring House Corporate Center P.O. Box 457 Spring House, PA 19477 , US
Priority Data:
10/418,78016.04.2003US
Title (EN) MODULATION OF APOLIPOPROTEIN C-III EXPRESSION
(FR) MODULATION DE L'EXPRESSION D'APOLIPOPROTEINE C-III
Abstract:
(EN) Compounds, compositions and methods are provided for modulating the expression of apolipoprotein C-III. The compositions comprise oligonucleotides, targeted to nucleic acid encoding apolipoprotein C-III. Methods of using these compounds for modulation of apolipoprotein C-III expression and for diagnosis and treatment of disease associated with expression of apolipoprotein C-III are provided.
(FR) L'invention concerne des composés, des compositions et des méthodes permettant de moduler l'expression d'apolipoprotéine C-III. Lesdites compositions comprennent des oligonucléotides, ciblés sur l'apolipoprotéine C-III codant l'acide nucléique. L'invention concerne également des méthodes faisant appel auxdits composés pour moduler l'expression de l'apolipoprotéine C-III et pour assurer le diagnostic et le traitement d'affections associées à l'expression de l'apolipoprotéine C-III.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP1622597ES2373101US20060264395EP2441449CA2522560ES2558949
EP3002007DK1622597DK2441449AU2013231079AU2004231550AU2010200324
CA2958943ES2666405