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1. WO2004092360 - THE SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS

Publication Number WO/2004/092360
Publication Date 28.10.2004
International Application No. PCT/US2004/011710
International Filing Date 09.04.2004
IPC
A61K 35/76 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
76Viruses; Subviral particles; Bacteriophages
A61K 38/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
A61K 39/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
A61K 39/215 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
215Coronaviridae, e.g. avian infectious bronchitis virus
C07K 14/165 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
165Coronaviridae, e.g. avian infectious bronchitis virus
C07K 16/10 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
08against material from viruses
10from RNA viruses
CPC
A61K 2039/5252
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
525Virus
5252inactivated (killed)
A61K 2039/545
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
545characterised by the dose, timing or administration schedule
A61K 2039/55505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
555characterised by a specific combination antigen/adjuvant
55505Inorganic adjuvants
A61K 2039/55511
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
555characterised by a specific combination antigen/adjuvant
55511Organic adjuvants
A61K 2039/55566
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
555characterised by a specific combination antigen/adjuvant
55511Organic adjuvants
55566Emulsions, e.g. Freund's adjuvant, MF59
A61K 39/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
Applicants
  • CHIRON CORPORATION [US]/[US] (AllExceptUS)
  • RAPPUOLI, Rino [IT]/[IT] (UsOnly)
  • MASIGNANI, Vega [IT]/[IT] (UsOnly)
  • STADLER, Konrad [DE]/[DE] (UsOnly)
  • GREGERSEN, Jens-Peter [DE]/[DE] (UsOnly)
  • CHIEN, David [US]/[US] (UsOnly)
  • HAN, Jang [US]/[US] (UsOnly)
  • POLO, John [US]/[US] (UsOnly)
  • WEINER, Amy [US]/[US] (UsOnly)
  • HOUGHTON, Michael [GB]/[US] (UsOnly)
  • SONG, Hyun, Chul [KR]/[US] (UsOnly)
  • SEO, Mi, Young [KR]/[US] (UsOnly)
  • DONNELLY, John, J. [US]/[US] (UsOnly)
  • KLENK, Hans, Dieter [DE]/[DE] (UsOnly)
  • VALIANTE, Nicholas [US]/[US] (UsOnly)
Inventors
  • RAPPUOLI, Rino
  • MASIGNANI, Vega
  • STADLER, Konrad
  • GREGERSEN, Jens-Peter
  • CHIEN, David
  • HAN, Jang
  • POLO, John
  • WEINER, Amy
  • HOUGHTON, Michael
  • SONG, Hyun, Chul
  • SEO, Mi, Young
  • DONNELLY, John, J.
  • KLENK, Hans, Dieter
  • VALIANTE, Nicholas
Agents
  • HALE, Rebecca, M.
Priority Data
60/462,21810.04.2003US
60/462,41812.04.2003US
60/462,46511.04.2003US
60/462,74813.04.2003US
60/463,10914.04.2003US
60/463,46015.04.2003US
60/463,66816.04.2003US
60/463,97118.04.2003US
60/463,98317.04.2003US
60/464,83822.04.2003US
60/464,89922.04.2003US
60/465,27323.04.2003US
60/465,53524.04.2003US
60/468,31205.05.2003US
60/473,14422.05.2003US
60/495,02414.08.2003US
60/505,65223.09.2003US
60/510,78111.10.2003US
60/529,46411.12.2003US
60/536,17712.01.2004US
60/560,75707.04.2004US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) THE SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS
(FR) LE CORONAVIRUS DU SYNDROME RESPIRATOIRE AIGU GRAVE
Abstract
(EN)
An outbreak of a virulent respiratory virus, now known as Severe Acute Respiratory Syndrome (SARS), was identified in Hong Kong, China and a growing number of countries around the world in 2003. The invention relates to nucleic acids and proteins from the SARS coronavirus. These nucleic acids and proteins can be used in the preparation and manufacture of vaccine formulations, diagnostic reagents, kits, etc. The invention also provides methods for treating SARS by administering small molecule antiviral compounds, as well as methods of identifying potent small molecules for the treatment of SARS.
(FR)
On a identifié une épidémie provoquée par un virus respiratoire, connu maintenant comme syndrome respiratoire aigu grave, à Hong Kong, en Chine et dans un nombre croissant de pays à travers le monde en 2003. L'invention a trait à des acides nucléiques et des protéines à partir du coronavirus du syndrome respiratoire aigu grave. Ces acides nucléiques et ces protéines peuvent être utilisés dans la préparation et la fabrication de formulations vaccinales, de réactifs de diagnostic, de trousses, et analogues. L'invention a également trait à des procédés pour le traitement du syndrome respiratoire aigu grave par l'administration de composés antiviraux de petites molécules, ainsi qu'à des procédés d'identification de petites molécules efficaces pour le traitement du syndrome respiratoire aigu grave.
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