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1. WO2004081013 - PROTEIN KINASE INHIBITORS

Publication Number WO/2004/081013
Publication Date 23.09.2004
International Application No. PCT/JP2004/003247
International Filing Date 11.03.2004
IPC
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A61K 31/519 (2006.01)
C07D 487/04 (2006.01)
CPC
A61K 31/519
C07D 487/04
Applicants
  • TEIJIN PHARMA LIMITED [JP/JP]; 1-1, Uchisaiwaicho 2-chome Chiyoda-ku Tokyo 1000011, JP (AllExceptUS)
  • KATAOKA, Kenichiro [JP/JP]; JP (UsOnly)
  • KOSUGI, Tomomi [JP/JP]; JP (UsOnly)
  • IMAI, Minoru [JP/JP]; JP (UsOnly)
  • MITCHELL, Dale, Robert [GB/GB]; GB (UsOnly)
  • SIMPSON, Donald, James [GB/GB]; GB (UsOnly)
  • CHURCH, Nicola, Jane [GB/GB]; GB (UsOnly)
  • SUZUKI, Naotaka [JP/JP]; JP (UsOnly)
  • YAMAKOSHI, Yuko [JP/JP]; JP (UsOnly)
Inventors
  • KATAOKA, Kenichiro; JP
  • KOSUGI, Tomomi; JP
  • IMAI, Minoru; JP
  • MITCHELL, Dale, Robert; GB
  • SIMPSON, Donald, James; GB
  • CHURCH, Nicola, Jane; GB
  • SUZUKI, Naotaka; JP
  • YAMAKOSHI, Yuko; JP
Agents
  • MIHARA, Hideko; c/o Teijin Intellectual Property Center Limited 1-1, Uchisaiwaicho 2-chome Chiyoda-ku Tokyo 1000011, JP
Priority Data
0305559.711.03.2003GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PROTEIN KINASE INHIBITORS
(FR) INHIBITEURS DE PROTEINE KINASE
Abstract
(EN)
The Pyrazolo[1,5-a]pyrimidine derivatives represented by formula I and their pharmaceutically acceptable salts exhibit excellent kinase inhibiting activity. Drugs comprising the compounds as effective ingredients are therefore expected to be useful as therapeutic or prophylactic agents for a protein kinase mediated disorder in which kinase is implicated, such as inflammatory disease, autoimmune disease, destructive bone disorder, cancer and/or tumour growth.
(FR)
Les dérivés de pyrazolo[1,5-a]pyrimidine de cette invention, représentés par la formule (I) et leurs sels acceptables d'un point de vue pharmaceutique, présentent une excellente activité inhibitrice de la protéine kinase. Les médicaments comprenant les composés comme ingrédients efficaces s'avèrent ainsi être utiles comme agents thérapeutiques ou prophylactiques dans une maladie induite par la protéine kinase dans laquelle la kinase est impliquée, telle qu'une maladie inflammatoire, une maladie auto-immune, la destruction osseuse, le cancer et/ou la croissance tumorale.
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