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1. (WO2004078763) THIADIBENZOAZULENE DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY DISEASES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2004/078763 International Application No.: PCT/HR2004/000005
Publication Date: 16.09.2004 International Filing Date: 05.03.2004
Chapter 2 Demand Filed: 23.09.2004
IPC:
C07D 495/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
495
Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
Applicants:
MERCEP, Mladen [HR/HR]; HR (UsOnly)
MESIC,Milan [HR/HR]; HR (UsOnly)
PESIC, Dijana [HR/HR]; HR (UsOnly)
BENKO, Iva [HR/HR]; HR (UsOnly)
PLIVA-ISTRAZIVACKI INSTITUT d.o.o. [HR/HR]; Prilaz baruna Filipovica 29 HR-10000 Zagreb, HR (AllExceptUS)
Inventors:
MERCEP, Mladen; HR
MESIC,Milan; HR
PESIC, Dijana; HR
BENKO, Iva; HR
Common
Representative:
PLIVA-ISTRAZIVACKI INSTITUT d.o.o.; Legal & Patent Affairs Prilaz baruna Filipovica 29 HR-10000 Zagreb, HR
Priority Data:
P20030160A06.03.2003HR
Title (EN) THIADIBENZOAZULENE DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY DISEASES
(FR) DERIVES DE THIADIBENZOAZULENE POUR LE TRAITEMENT DE MALADIES INFLAMMATOIRES
Abstract:
(EN) The present invention relates to novel 1-thia-dibenzoazulene derivatives of the formula (I), wherein X individually denotes a hetero atom -O- or -S-; Y and Z independently from each other individually denote a fragment of the formula (II) to their pharmacologically acceptable esters, salts and solvates, to processes and intermediates for the preparation thereof, to a process for preparing pharmaceutical formulations for the treatment of inflammatory diseases and conditions and to the use thereof in the treatment of inflammatory diseases and conditions in humans and animals. These compounds inhibit tumour necrosis factor-&agr;(TNF-(&agr;) production and interleukin-1 (IL-1) production and exhibit an analgetic action.
(FR) L'invention concerne de nouveaux dérivés de 1-thia-dibenzoazulène de formule (I). Dans cette formule, X désigne individuellement un hétéroatome -O- ou -S-; Y et Z, indépendamment l'un de l'autre, désignent individuellement un fragment de la formule (II) (O-(CH2)m-A). L'invention concerne des esters pharmacologiquement acceptables, des sels et des solvants de ces dérivés. L'invention concerne également des procédés et des intermédiaires pour leur préparation. L'invention concerne encore un procédé pour préparer des formulations pharmaceutiques pour le traitement de maladies et de troubles inflammatoires, et l'utilisation de ces formulations dans le traitement de maladies et de troubles inflammatoires chez les humains et chez les animaux. Ces composés inhibent la production d'un facteur de nécrose tumorale $g(a) (TNF-$g(a)) et la production d'interleukine-1 (IL-1) et présentent une action analgésique.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)