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1. WO2004078763 - THIADIBENZOAZULENE DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY DISEASES

Publication Number WO/2004/078763
Publication Date 16.09.2004
International Application No. PCT/HR2004/000005
International Filing Date 05.03.2004
Chapter 2 Demand Filed 23.09.2004
IPC
C07D 495/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
495Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
CPC
A61P 1/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
A61P 11/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
06Antiasthmatics
A61P 17/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
A61P 17/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
02for treating wounds, ulcers, burns, scars, keloids, or the like
A61P 17/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
06Antipsoriatics
A61P 19/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
02for joint disorders, e.g. arthritis, arthrosis
Applicants
  • PLIVA-ISTRAZIVACKI INSTITUT d.o.o. [HR]/[HR] (AllExceptUS)
  • MERCEP, Mladen [HR]/[HR] (UsOnly)
  • MESIC,Milan [HR]/[HR] (UsOnly)
  • PESIC, Dijana [HR]/[HR] (UsOnly)
  • BENKO, Iva [HR]/[HR] (UsOnly)
Inventors
  • MERCEP, Mladen
  • MESIC,Milan
  • PESIC, Dijana
  • BENKO, Iva
Common Representative
  • PLIVA-ISTRAZIVACKI INSTITUT d.o.o.
Priority Data
P20030160A06.03.2003HR
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) THIADIBENZOAZULENE DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY DISEASES
(FR) DERIVES DE THIADIBENZOAZULENE POUR LE TRAITEMENT DE MALADIES INFLAMMATOIRES
Abstract
(EN) The present invention relates to novel 1-thia-dibenzoazulene derivatives of the formula (I), wherein X individually denotes a hetero atom -O- or -S-; Y and Z independently from each other individually denote a fragment of the formula (II) to their pharmacologically acceptable esters, salts and solvates, to processes and intermediates for the preparation thereof, to a process for preparing pharmaceutical formulations for the treatment of inflammatory diseases and conditions and to the use thereof in the treatment of inflammatory diseases and conditions in humans and animals. These compounds inhibit tumour necrosis factor-&agr;(TNF-(&agr;) production and interleukin-1 (IL-1) production and exhibit an analgetic action.
(FR) L'invention concerne de nouveaux dérivés de 1-thia-dibenzoazulène de formule (I). Dans cette formule, X désigne individuellement un hétéroatome -O- ou -S-; Y et Z, indépendamment l'un de l'autre, désignent individuellement un fragment de la formule (II) (O-(CH2)m-A). L'invention concerne des esters pharmacologiquement acceptables, des sels et des solvants de ces dérivés. L'invention concerne également des procédés et des intermédiaires pour leur préparation. L'invention concerne encore un procédé pour préparer des formulations pharmaceutiques pour le traitement de maladies et de troubles inflammatoires, et l'utilisation de ces formulations dans le traitement de maladies et de troubles inflammatoires chez les humains et chez les animaux. Ces composés inhibent la production d'un facteur de nécrose tumorale $g(a) (TNF-$g(a)) et la production d'interleukine-1 (IL-1) et présentent une action analgésique.
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